Long Non-Coding RNA in the Pathogenesis of Cancers
The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surger...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/9/1015 |
| _version_ | 1827835891121389568 |
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| author | Yujing Chi Di Wang Junpei Wang Weidong Yu Jichun Yang |
| author_facet | Yujing Chi Di Wang Junpei Wang Weidong Yu Jichun Yang |
| author_sort | Yujing Chi |
| collection | DOAJ |
| description | The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma. |
| first_indexed | 2024-03-12T06:17:41Z |
| format | Article |
| id | doaj.art-6aa355fea1294edf8269c93748d6638f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:17:41Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6aa355fea1294edf8269c93748d6638f2023-09-03T02:27:13ZengMDPI AGCells2073-44092019-09-0189101510.3390/cells8091015cells8091015Long Non-Coding RNA in the Pathogenesis of CancersYujing Chi0Di Wang1Junpei Wang2Weidong Yu3Jichun Yang4Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, ChinaThe incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma.https://www.mdpi.com/2073-4409/8/9/1015lncRNAscancerproliferationmetastasis |
| spellingShingle | Yujing Chi Di Wang Junpei Wang Weidong Yu Jichun Yang Long Non-Coding RNA in the Pathogenesis of Cancers Cells lncRNAs cancer proliferation metastasis |
| title | Long Non-Coding RNA in the Pathogenesis of Cancers |
| title_full | Long Non-Coding RNA in the Pathogenesis of Cancers |
| title_fullStr | Long Non-Coding RNA in the Pathogenesis of Cancers |
| title_full_unstemmed | Long Non-Coding RNA in the Pathogenesis of Cancers |
| title_short | Long Non-Coding RNA in the Pathogenesis of Cancers |
| title_sort | long non coding rna in the pathogenesis of cancers |
| topic | lncRNAs cancer proliferation metastasis |
| url | https://www.mdpi.com/2073-4409/8/9/1015 |
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