COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS
Abstract. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium tuberculosis.Similar differences in dynamics...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/633 |
| _version_ | 1797198019276308480 |
|---|---|
| author | D. V. Balunets L. N. Nesterenko Yu. S. Romanova Yu. S. Alyapkina N. I. Kolkova A. S. Apt |
| author_facet | D. V. Balunets L. N. Nesterenko Yu. S. Romanova Yu. S. Alyapkina N. I. Kolkova A. S. Apt |
| author_sort | D. V. Balunets |
| collection | DOAJ |
| description | Abstract. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium tuberculosis.Similar differences in dynamics of some common parameters (life span and pathogen numbers in affected or gans) between A/Sn and I/St mice have been revealed for tuberculosis, salmonellosis and chlamidiasis. There has been demonstrated that A/Sn animals show increased resistance to Salmonella and Chlamidia infections, as compared to I/St mice, in spite of various mechanisms of intracellular parasitism for S.typhimurium and C.Pneumoniae, and different locations of lesions induced by these bacteria in the host organism.Similar features of quite different infections at the level of macroorganism allows us to suggest that further investigation in A/Sn and I/St murine model will make it able to discover the basic features of physiolog$ical control for a lot of infections, and to reveal a genetic network that could be responsible for their favorable or adverse outcomes. (Med. Immunol., 2005, vol.7, № 5–6, pp. 583–586) |
| first_indexed | 2024-03-08T05:49:41Z |
| format | Article |
| id | doaj.art-6aa3cf07e42d43e2842cea1307db274f |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:12Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-6aa3cf07e42d43e2842cea1307db274f2024-04-22T13:07:38ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0175-658358610.15789/1563-0625-2005-5-6-583-586630COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSISD. V. Balunets0L. N. Nesterenko1Yu. S. Romanova2Yu. S. Alyapkina3N. I. Kolkova4A. S. Apt5ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМНГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМНГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМНГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМНГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМНГУ Центральный НИИ туберкулеза РАМН, МоскваAbstract. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium tuberculosis.Similar differences in dynamics of some common parameters (life span and pathogen numbers in affected or gans) between A/Sn and I/St mice have been revealed for tuberculosis, salmonellosis and chlamidiasis. There has been demonstrated that A/Sn animals show increased resistance to Salmonella and Chlamidia infections, as compared to I/St mice, in spite of various mechanisms of intracellular parasitism for S.typhimurium and C.Pneumoniae, and different locations of lesions induced by these bacteria in the host organism.Similar features of quite different infections at the level of macroorganism allows us to suggest that further investigation in A/Sn and I/St murine model will make it able to discover the basic features of physiolog$ical control for a lot of infections, and to reveal a genetic network that could be responsible for their favorable or adverse outcomes. (Med. Immunol., 2005, vol.7, № 5–6, pp. 583–586)https://www.mimmun.ru/mimmun/article/view/633mycobacterium tuberculosischlamidiasissalmonellosisinbred strains of mice |
| spellingShingle | D. V. Balunets L. N. Nesterenko Yu. S. Romanova Yu. S. Alyapkina N. I. Kolkova A. S. Apt COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS Медицинская иммунология mycobacterium tuberculosis chlamidiasis salmonellosis inbred strains of mice |
| title | COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS |
| title_full | COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS |
| title_fullStr | COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS |
| title_full_unstemmed | COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS |
| title_short | COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS |
| title_sort | comparative analysis of development of chlamydophila and salmonella infections in the inbred mice different in their sensitivites to m tuberculosis |
| topic | mycobacterium tuberculosis chlamidiasis salmonellosis inbred strains of mice |
| url | https://www.mimmun.ru/mimmun/article/view/633 |
| work_keys_str_mv | AT dvbalunets comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis AT lnnesterenko comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis AT yusromanova comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis AT yusalyapkina comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis AT nikolkova comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis AT asapt comparativeanalysisofdevelopmentofchlamydophilaandsalmonellainfectionsintheinbredmicedifferentintheirsensitivitestomtuberculosis |