Abnormal bile acid absorption in familial hypertriglyceridemia
To better define the abnormality of bile acid metabolism associated with hypertriglyceridemia, we measured bile acid kinetics and absorption as well as preferential use of newly synthesized cholesterol for bile acid synthesis in eleven controls and ten subjects with hypertriglyceridemia, six of whom...
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| Format: | Article |
| Language: | English |
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Elsevier
1995-01-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520397583 |
| _version_ | 1818715823767814144 |
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| author | W C Duane |
| author_facet | W C Duane |
| author_sort | W C Duane |
| collection | DOAJ |
| description | To better define the abnormality of bile acid metabolism associated with hypertriglyceridemia, we measured bile acid kinetics and absorption as well as preferential use of newly synthesized cholesterol for bile acid synthesis in eleven controls and ten subjects with hypertriglyceridemia, six of whom could be classified as having familial hypertriglyceridemia (FHT). Fractional turnover rates of cholic acid and chenodeoxycholic acid were both significantly elevated in hypertriglyceridemic subjects to nearly twice the rates in controls. Bile acid synthesis was also significantly higher in hypertriglyceridemic subjects while bile acid pools were either unchanged or somewhat reduced. Consistent with these kinetics, bile acid absorption was significantly lower in hypertriglyceridemic subjects than in controls. Overall only 10-12% of bile acid was derived from newly synthesized cholesterol, and hypertriglyceridemic subjects did not differ from controls. Because hypertriglyceridemia should not alter bile acid absorption, these results are consistent with the previously suggested possibility (B. Angelin, K. S. Hershon, and J. D. Brunzell, 1987. Proc. Natl. Acad. Sci. USA. 84: 5434-5438) that impaired bile acid absorption may be a primary defect in some patients with hypertriglyceridemia. |
| first_indexed | 2024-12-17T19:09:29Z |
| format | Article |
| id | doaj.art-6aa7445e26e14dfe8a2ed45320c6fe18 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T19:09:29Z |
| publishDate | 1995-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-6aa7445e26e14dfe8a2ed45320c6fe182022-12-21T21:35:54ZengElsevierJournal of Lipid Research0022-22751995-01-0136196107Abnormal bile acid absorption in familial hypertriglyceridemiaW C Duane0Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN 55417.To better define the abnormality of bile acid metabolism associated with hypertriglyceridemia, we measured bile acid kinetics and absorption as well as preferential use of newly synthesized cholesterol for bile acid synthesis in eleven controls and ten subjects with hypertriglyceridemia, six of whom could be classified as having familial hypertriglyceridemia (FHT). Fractional turnover rates of cholic acid and chenodeoxycholic acid were both significantly elevated in hypertriglyceridemic subjects to nearly twice the rates in controls. Bile acid synthesis was also significantly higher in hypertriglyceridemic subjects while bile acid pools were either unchanged or somewhat reduced. Consistent with these kinetics, bile acid absorption was significantly lower in hypertriglyceridemic subjects than in controls. Overall only 10-12% of bile acid was derived from newly synthesized cholesterol, and hypertriglyceridemic subjects did not differ from controls. Because hypertriglyceridemia should not alter bile acid absorption, these results are consistent with the previously suggested possibility (B. Angelin, K. S. Hershon, and J. D. Brunzell, 1987. Proc. Natl. Acad. Sci. USA. 84: 5434-5438) that impaired bile acid absorption may be a primary defect in some patients with hypertriglyceridemia.http://www.sciencedirect.com/science/article/pii/S0022227520397583 |
| spellingShingle | W C Duane Abnormal bile acid absorption in familial hypertriglyceridemia Journal of Lipid Research |
| title | Abnormal bile acid absorption in familial hypertriglyceridemia |
| title_full | Abnormal bile acid absorption in familial hypertriglyceridemia |
| title_fullStr | Abnormal bile acid absorption in familial hypertriglyceridemia |
| title_full_unstemmed | Abnormal bile acid absorption in familial hypertriglyceridemia |
| title_short | Abnormal bile acid absorption in familial hypertriglyceridemia |
| title_sort | abnormal bile acid absorption in familial hypertriglyceridemia |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520397583 |
| work_keys_str_mv | AT wcduane abnormalbileacidabsorptioninfamilialhypertriglyceridemia |