Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the re...

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Bibliografiske detaljer
Main Authors: Ewa K Bomba-Warczak, Karen M Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew L Steinhauser, Jeffrey N Savas, Francesca E Duncan
Format: Article
Sprog:English
Udgivet: eLife Sciences Publications Ltd 2024-10-01
Serier:eLife
Fag:
long-lived proteins
oocyte
ovaries
proteomics
mass spectrometry imaging
reproductive aging
Online adgang:https://elifesciences.org/articles/93172

Internet

https://elifesciences.org/articles/93172

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