Identification of Common and Subtype-Specific Mutated Sub-Pathways for a Cancer

Identification of Common and Subtype-Specific Mutated Sub-Pathways for a Cancer

The heterogeneity of cancer is a big obstacle for cancer diagnosis and treatment. Prioritizing combinations of driver genes that mutate in most patients of a specific cancer or a subtype of this cancer is a promising way to tackle this problem. Here, we developed an empirical algorithm, named PathMG...

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Bibliographic Details
Main Authors: Haidan Yan, Xusheng Deng, Haifeng Chen, Jun Cheng, Jun He, Qingzhou Guan, Meifeng Li, Jiajing Xie, Jie Xia, Yunyan Gu, Zheng Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
mutation
common sub-pathways
subtype-specific sub-pathways
cancer genes
drug targets
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01228/full

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