The Effects of Topical Ketamine in Reducing Venipuncture Pain
Background: Different pharmacological methods have been introduced for managing venipuncture pain. The aim of this study was to evaluate the effect of topical ketamine in reducing the pain of venipuncture. Methods: In this randomized clinical trial study, 200 patients with indication for venipunctu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2019-10-01
|
| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/12130 |
| _version_ | 1797710299530264576 |
|---|---|
| author | Farhad Heydari Sanaz Khalilian Keihan Golshani Saeed Majidinejad Babak Masoumi |
| author_facet | Farhad Heydari Sanaz Khalilian Keihan Golshani Saeed Majidinejad Babak Masoumi |
| author_sort | Farhad Heydari |
| collection | DOAJ |
| description | Background: Different pharmacological methods have been introduced for managing venipuncture pain. The aim of this study was to evaluate the effect of topical ketamine in reducing the pain of venipuncture.
Methods: In this randomized clinical trial study, 200 patients with indication for venipuncture were enrolled. Patients were randomly divided into two groups. In the first group, the venipuncture site was covered with topical ketamine and in the second group, with placebo. After 45 minutes, the site was examined for numbness, and when complete numbness achieved, professional nurses performed the venipuncture. Then, pain severity [by visual analog scale (VAS)] and side effects were recorded and compared between the groups.
Findings: The mean age of patients was 45.15 ± 10.36 years and 50% were men. There was no statistically significant difference between the two groups in terms of age and sex. VAS was significantly lower in the ketamine group than in the control group (P < 0.001); but the side effects such as redness, hives, itching, and burning were significantly less in control group (P < 0.050). The mean duration of complete numbness in the ketamine group was 58.20 ± 9.48 hours (P < 0.050).
Conclusion: Topical ketamine is effective in reducing the pain of venipuncture in adult. To expect a full effect, ketamine cream should be applied at least 60 minutes prior to cannulation. |
| first_indexed | 2024-03-12T06:50:10Z |
| format | Article |
| id | doaj.art-6aab60ed2ea24ce2909ae00e5b57d0fb |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T06:50:10Z |
| publishDate | 2019-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-6aab60ed2ea24ce2909ae00e5b57d0fb2023-09-03T00:20:35ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-10-013753789790210.22122/jims.v37i537.121303472The Effects of Topical Ketamine in Reducing Venipuncture PainFarhad Heydari0Sanaz Khalilian1Keihan Golshani2Saeed Majidinejad3Babak Masoumi4Assistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranEmergency Medicine Specialist, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Emergency Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Different pharmacological methods have been introduced for managing venipuncture pain. The aim of this study was to evaluate the effect of topical ketamine in reducing the pain of venipuncture. Methods: In this randomized clinical trial study, 200 patients with indication for venipuncture were enrolled. Patients were randomly divided into two groups. In the first group, the venipuncture site was covered with topical ketamine and in the second group, with placebo. After 45 minutes, the site was examined for numbness, and when complete numbness achieved, professional nurses performed the venipuncture. Then, pain severity [by visual analog scale (VAS)] and side effects were recorded and compared between the groups. Findings: The mean age of patients was 45.15 ± 10.36 years and 50% were men. There was no statistically significant difference between the two groups in terms of age and sex. VAS was significantly lower in the ketamine group than in the control group (P < 0.001); but the side effects such as redness, hives, itching, and burning were significantly less in control group (P < 0.050). The mean duration of complete numbness in the ketamine group was 58.20 ± 9.48 hours (P < 0.050). Conclusion: Topical ketamine is effective in reducing the pain of venipuncture in adult. To expect a full effect, ketamine cream should be applied at least 60 minutes prior to cannulation.http://jims.mui.ac.ir/index.php/jims/article/view/12130ketamineemergency departmentsvenipuncturepain |
| spellingShingle | Farhad Heydari Sanaz Khalilian Keihan Golshani Saeed Majidinejad Babak Masoumi The Effects of Topical Ketamine in Reducing Venipuncture Pain مجله دانشکده پزشکی اصفهان ketamine emergency departments venipuncture pain |
| title | The Effects of Topical Ketamine in Reducing Venipuncture Pain |
| title_full | The Effects of Topical Ketamine in Reducing Venipuncture Pain |
| title_fullStr | The Effects of Topical Ketamine in Reducing Venipuncture Pain |
| title_full_unstemmed | The Effects of Topical Ketamine in Reducing Venipuncture Pain |
| title_short | The Effects of Topical Ketamine in Reducing Venipuncture Pain |
| title_sort | effects of topical ketamine in reducing venipuncture pain |
| topic | ketamine emergency departments venipuncture pain |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/12130 |
| work_keys_str_mv | AT farhadheydari theeffectsoftopicalketamineinreducingvenipuncturepain AT sanazkhalilian theeffectsoftopicalketamineinreducingvenipuncturepain AT keihangolshani theeffectsoftopicalketamineinreducingvenipuncturepain AT saeedmajidinejad theeffectsoftopicalketamineinreducingvenipuncturepain AT babakmasoumi theeffectsoftopicalketamineinreducingvenipuncturepain AT farhadheydari effectsoftopicalketamineinreducingvenipuncturepain AT sanazkhalilian effectsoftopicalketamineinreducingvenipuncturepain AT keihangolshani effectsoftopicalketamineinreducingvenipuncturepain AT saeedmajidinejad effectsoftopicalketamineinreducingvenipuncturepain AT babakmasoumi effectsoftopicalketamineinreducingvenipuncturepain |