Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression
Background: Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622001478 |
| _version_ | 1797991122468864000 |
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| author | Xiaoyue Qin Chuyu Pan Qingqing Cai Yijing Zhao Dan He Wenming Wei Na Zhang Sirong Shi Xiaoge Chu Feng Zhang |
| author_facet | Xiaoyue Qin Chuyu Pan Qingqing Cai Yijing Zhao Dan He Wenming Wei Na Zhang Sirong Shi Xiaoge Chu Feng Zhang |
| author_sort | Xiaoyue Qin |
| collection | DOAJ |
| description | Background: Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and explore candidate genes involving the interactions. Methods: Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn's disease (CD), and total IBD (CD + UC) respectively. The effects of interactions between gut microbiome and IBD on depression were assessed through a linear regression model. Moreover, for observed significant interactions between gut microbiome PRS and IBD PRS, PLINK software was used to test pair-wise single nucleotide polymorphisms (SNPs) interaction of corresponding gut microbiome PRS and IBD PRS on depression. Results: We found 64 candidate interactions between gut microbiome and IBD on four phenotypes of depression, such as F_Lachnospiraceae (RNT) × (CD + UC) for patient health questionnaire-9 (PHQ-9) score (P = 1.48 × 10−3), F_Veillonellaceae (HB) × UC for self-reported depression (P = 2.83 × 10−3) and P_Firmicutes (RNT) × CD for age at first episode of depression (P = 8.50 × 10−3). We observed interactions of gut-microbiome-associated SNPs × IBD-associated SNPs, such as G_Alloprevotella (HB)-associated rs147650986 (GPM6A) × IBD-associated rs114471990 (QRICH1) (P = 2.26 × 10−4). Conclusion: Our results support the effects of interactions between gut microbiome and IBD on depression risk, and reported several novel candidate genes for depression. |
| first_indexed | 2024-04-11T08:47:28Z |
| format | Article |
| id | doaj.art-6aace0cc65b5479aab505cc952bf744c |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-11T08:47:28Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-6aace0cc65b5479aab505cc952bf744c2022-12-22T04:33:55ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-12-0126100557Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depressionXiaoyue Qin0Chuyu Pan1Qingqing Cai2Yijing Zhao3Dan He4Wenming Wei5Na Zhang6Sirong Shi7Xiaoge Chu8Feng Zhang9Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaKey Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaCorresponding author. Key Laboratory of Trace Elements and Endemic Diseases, National Health Commission of the People’s Republic of China, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, 71006, China.; Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, ChinaBackground: Gut microbiome and inflammatory bowel disease (IBD) are implicated in the development of depression, but the effect of their interactions on the risk of depression remains unclear. We aim to analyze the effect of interactions between gut microbiome and IBD on the risk of depression, and explore candidate genes involving the interactions. Methods: Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn's disease (CD), and total IBD (CD + UC) respectively. The effects of interactions between gut microbiome and IBD on depression were assessed through a linear regression model. Moreover, for observed significant interactions between gut microbiome PRS and IBD PRS, PLINK software was used to test pair-wise single nucleotide polymorphisms (SNPs) interaction of corresponding gut microbiome PRS and IBD PRS on depression. Results: We found 64 candidate interactions between gut microbiome and IBD on four phenotypes of depression, such as F_Lachnospiraceae (RNT) × (CD + UC) for patient health questionnaire-9 (PHQ-9) score (P = 1.48 × 10−3), F_Veillonellaceae (HB) × UC for self-reported depression (P = 2.83 × 10−3) and P_Firmicutes (RNT) × CD for age at first episode of depression (P = 8.50 × 10−3). We observed interactions of gut-microbiome-associated SNPs × IBD-associated SNPs, such as G_Alloprevotella (HB)-associated rs147650986 (GPM6A) × IBD-associated rs114471990 (QRICH1) (P = 2.26 × 10−4). Conclusion: Our results support the effects of interactions between gut microbiome and IBD on depression risk, and reported several novel candidate genes for depression.http://www.sciencedirect.com/science/article/pii/S2666354622001478Gut microbiomeInflammatory bowel disease (IBD)Depression |
| spellingShingle | Xiaoyue Qin Chuyu Pan Qingqing Cai Yijing Zhao Dan He Wenming Wei Na Zhang Sirong Shi Xiaoge Chu Feng Zhang Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression Brain, Behavior, & Immunity - Health Gut microbiome Inflammatory bowel disease (IBD) Depression |
| title | Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| title_full | Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| title_fullStr | Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| title_full_unstemmed | Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| title_short | Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| title_sort | assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression |
| topic | Gut microbiome Inflammatory bowel disease (IBD) Depression |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622001478 |
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