Extensive impact of low-frequency variants on the phenotypic landscape at population-scale

Extensive impact of low-frequency variants on the phenotypic landscape at population-scale

Genome-wide association studies (GWAS) allow to dissect complex traits and map genetic variants, which often explain relatively little of the heritability. One potential reason is the preponderance of undetected low-frequency variants. To increase their allele frequency and assess their phenotypic i...

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Bibliographic Details
Main Authors: Téo Fournier, Omar Abou Saada, Jing Hou, Jackson Peter, Elodie Caudal, Joseph Schacherer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
genetic architecture
GWAS
low-frequency variants
Online Access:https://elifesciences.org/articles/49258

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