Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study
Background: Infection due to nontuberculous mycobacteria (NTM) is an emerging issue worldwide, and we aimed to address the epidemiology and mortality association of NTM infection requiring treatment in Taiwan. Methods: We used the 2003–2018 data of 2 million representative individuals in Taiwan’s Na...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-06-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/17534666221103213 |
| _version_ | 1797853320135573504 |
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| author | Hsin-Hua Chen Ching-Heng Lin Wen-Cheng Chao |
| author_facet | Hsin-Hua Chen Ching-Heng Lin Wen-Cheng Chao |
| author_sort | Hsin-Hua Chen |
| collection | DOAJ |
| description | Background: Infection due to nontuberculous mycobacteria (NTM) is an emerging issue worldwide, and we aimed to address the epidemiology and mortality association of NTM infection requiring treatment in Taiwan. Methods: We used the 2003–2018 data of 2 million representative individuals in Taiwan’s National Health Insurance Research Database. We identified patients with newly diagnosed NTM infection and received treatment as NTM cases. Age- and sex-matched (1:40) as well as propensity score-matched (PSM) (1:2) non-NTM individuals were selected as non-NTM controls. We used a Cox proportional hazard model to determine hazard ratios (HRs) with 95% confidence intervals (CIs). Results: We identified 558 patients with NTM infection requiring treatment. The mean age was 62.5 ± 15.4 years, and 57.5% of them were male. The incidence increased from 0.54 per 100,000 person-year in 2003 to 3.35 per 100,000 person-year in 2018. The overall mortality was 35.2%, with a mean follow-up duration of 4.1 ± 3.6 years. We found that NTM infection was independently associated with a greater risk of mortality (HR: 1.71; 95% CI: 1.47–1.98) compared with age- and sex-matched controls, and the association remained consistent (HR: 1.44; 95% CI: 1.19–1.75) compared with propensity-matched controls. We also found that old age, male, high Charlson comorbidity index, and the use of steroids or anti-neoplastic agents/immunosuppressants were associated with mortality risk. Conclusion: In conclusion, we found a steady increase in patients with NTM infection requiring treatment in Taiwan and further demonstrated that NTM infection was associated with greater risk of mortality using two comparable non-NTM control subjects. |
| first_indexed | 2024-04-09T19:47:38Z |
| format | Article |
| id | doaj.art-6ab0ef49a10a46e2bf3bb0fefb51a66e |
| institution | Directory Open Access Journal |
| issn | 1753-4666 |
| language | English |
| last_indexed | 2024-04-09T19:47:38Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-6ab0ef49a10a46e2bf3bb0fefb51a66e2023-04-03T13:35:48ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46662022-06-011610.1177/17534666221103213Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based studyHsin-Hua ChenChing-Heng LinWen-Cheng ChaoBackground: Infection due to nontuberculous mycobacteria (NTM) is an emerging issue worldwide, and we aimed to address the epidemiology and mortality association of NTM infection requiring treatment in Taiwan. Methods: We used the 2003–2018 data of 2 million representative individuals in Taiwan’s National Health Insurance Research Database. We identified patients with newly diagnosed NTM infection and received treatment as NTM cases. Age- and sex-matched (1:40) as well as propensity score-matched (PSM) (1:2) non-NTM individuals were selected as non-NTM controls. We used a Cox proportional hazard model to determine hazard ratios (HRs) with 95% confidence intervals (CIs). Results: We identified 558 patients with NTM infection requiring treatment. The mean age was 62.5 ± 15.4 years, and 57.5% of them were male. The incidence increased from 0.54 per 100,000 person-year in 2003 to 3.35 per 100,000 person-year in 2018. The overall mortality was 35.2%, with a mean follow-up duration of 4.1 ± 3.6 years. We found that NTM infection was independently associated with a greater risk of mortality (HR: 1.71; 95% CI: 1.47–1.98) compared with age- and sex-matched controls, and the association remained consistent (HR: 1.44; 95% CI: 1.19–1.75) compared with propensity-matched controls. We also found that old age, male, high Charlson comorbidity index, and the use of steroids or anti-neoplastic agents/immunosuppressants were associated with mortality risk. Conclusion: In conclusion, we found a steady increase in patients with NTM infection requiring treatment in Taiwan and further demonstrated that NTM infection was associated with greater risk of mortality using two comparable non-NTM control subjects.https://doi.org/10.1177/17534666221103213 |
| spellingShingle | Hsin-Hua Chen Ching-Heng Lin Wen-Cheng Chao Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study Therapeutic Advances in Respiratory Disease |
| title | Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study |
| title_full | Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study |
| title_fullStr | Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study |
| title_full_unstemmed | Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study |
| title_short | Mortality association of nontuberculous mycobacterial infection requiring treatment in Taiwan: a population-based study |
| title_sort | mortality association of nontuberculous mycobacterial infection requiring treatment in taiwan a population based study |
| url | https://doi.org/10.1177/17534666221103213 |
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