RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment
Abstract Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endogenous proteins that can bind to mRNAs and modify (or even determine) the amount of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03245-6 |
| _version_ | 1828127353850560512 |
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| author | Jiangchun Wu Yong Wu Qinhao Guo Simin Wang Xiaohua Wu |
| author_facet | Jiangchun Wu Yong Wu Qinhao Guo Simin Wang Xiaohua Wu |
| author_sort | Jiangchun Wu |
| collection | DOAJ |
| description | Abstract Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endogenous proteins that can bind to mRNAs and modify (or even determine) the amount of protein they can generate, have attracted great attention in the context of various diseases, especially cancers. Compelling studies have suggested that RBPs are aberrantly expressed in different cancer tissues and cell types, including OC tissues and cells. More specifically, RBPs can regulate proliferation, apoptosis, invasion, metastasis, tumorigenesis and chemosensitivity and serve as potential therapeutic targets in OC. Herein, we summarize what is currently known about the biogenesis, molecular functions and potential roles of human RBPs in OC and their prospects for application in the clinical treatment of OC. |
| first_indexed | 2024-04-11T15:49:09Z |
| format | Article |
| id | doaj.art-6ab0fe6134934b079627bf178734f34e |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T15:49:09Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-6ab0fe6134934b079627bf178734f34e2022-12-22T04:15:26ZengBMCJournal of Translational Medicine1479-58762022-01-0120111410.1186/s12967-022-03245-6RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatmentJiangchun Wu0Yong Wu1Qinhao Guo2Simin Wang3Xiaohua Wu4Department of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityAbstract Ovarian cancer (OC), an important cause of cancer-related death in women worldwide, is one of the most malignant cancers and is characterized by a poor prognosis. RNA-binding proteins (RBPs), a class of endogenous proteins that can bind to mRNAs and modify (or even determine) the amount of protein they can generate, have attracted great attention in the context of various diseases, especially cancers. Compelling studies have suggested that RBPs are aberrantly expressed in different cancer tissues and cell types, including OC tissues and cells. More specifically, RBPs can regulate proliferation, apoptosis, invasion, metastasis, tumorigenesis and chemosensitivity and serve as potential therapeutic targets in OC. Herein, we summarize what is currently known about the biogenesis, molecular functions and potential roles of human RBPs in OC and their prospects for application in the clinical treatment of OC.https://doi.org/10.1186/s12967-022-03245-6Ovarian cancerRNA-binding proteinsTherapeutic targets |
| spellingShingle | Jiangchun Wu Yong Wu Qinhao Guo Simin Wang Xiaohua Wu RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment Journal of Translational Medicine Ovarian cancer RNA-binding proteins Therapeutic targets |
| title | RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment |
| title_full | RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment |
| title_fullStr | RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment |
| title_full_unstemmed | RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment |
| title_short | RNA-binding proteins in ovarian cancer: a novel avenue of their roles in diagnosis and treatment |
| title_sort | rna binding proteins in ovarian cancer a novel avenue of their roles in diagnosis and treatment |
| topic | Ovarian cancer RNA-binding proteins Therapeutic targets |
| url | https://doi.org/10.1186/s12967-022-03245-6 |
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