Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome
BackgroundIt has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1115482/full |
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| author | Heqing Zheng Lanxiang Wu Sheng Tian Mingxu Liu Qingqing Zhan Xinping Yu Yonggang Xie Xianhui Zhong Wei Wu |
| author_facet | Heqing Zheng Lanxiang Wu Sheng Tian Mingxu Liu Qingqing Zhan Xinping Yu Yonggang Xie Xianhui Zhong Wei Wu |
| author_sort | Heqing Zheng |
| collection | DOAJ |
| description | BackgroundIt has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of BTX-A on NMS and QoL and to clarify the relationship between changes in motor symptoms, NMS, and QoL after BTX-A.MethodsSeventy-five patients were recruited for the study. All patients were assessed by a series of clinical assessments before, one, and 3 months after BTX-A treatment. Dystonic symptoms, psychiatric disturbances, sleep disorders, and QoL were evaluated.ResultsAfter 1 and 3 months of BTX-A treatment, the scores of motor symptoms, anxiety, and depression were significantly decreased (P < 0.05). Except for general health, the scores of the other 36-item short-form health survey QoL subitems were significantly improved after BTX-A (P < 0.05). After 1 month of treatment, the changes in anxiety and depression were not correlated with changes in motor symptoms (P > 0.05). Still, they were negatively correlated with changes in physical functioning, role-physical and mental component summary QoL (P < 0.05).ConclusionsBTX-A effectively improved motor symptoms, anxiety, depression, and QoL. Anxiety and depression improvement did not correlate with motor symptom changes after BTX-A, and QoL improvements were strongly associated with psychiatric disturbances. |
| first_indexed | 2024-04-10T16:23:32Z |
| format | Article |
| id | doaj.art-6ab13638f2a3440382ea4429d4e38196 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T16:23:32Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6ab13638f2a3440382ea4429d4e381962023-02-09T10:13:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-02-011410.3389/fneur.2023.11154821115482Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndromeHeqing ZhengLanxiang WuSheng TianMingxu LiuQingqing ZhanXinping YuYonggang XieXianhui ZhongWei WuBackgroundIt has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of BTX-A on NMS and QoL and to clarify the relationship between changes in motor symptoms, NMS, and QoL after BTX-A.MethodsSeventy-five patients were recruited for the study. All patients were assessed by a series of clinical assessments before, one, and 3 months after BTX-A treatment. Dystonic symptoms, psychiatric disturbances, sleep disorders, and QoL were evaluated.ResultsAfter 1 and 3 months of BTX-A treatment, the scores of motor symptoms, anxiety, and depression were significantly decreased (P < 0.05). Except for general health, the scores of the other 36-item short-form health survey QoL subitems were significantly improved after BTX-A (P < 0.05). After 1 month of treatment, the changes in anxiety and depression were not correlated with changes in motor symptoms (P > 0.05). Still, they were negatively correlated with changes in physical functioning, role-physical and mental component summary QoL (P < 0.05).ConclusionsBTX-A effectively improved motor symptoms, anxiety, depression, and QoL. Anxiety and depression improvement did not correlate with motor symptom changes after BTX-A, and QoL improvements were strongly associated with psychiatric disturbances.https://www.frontiersin.org/articles/10.3389/fneur.2023.1115482/fullMeige syndromenon-motor symptomsbotulinum toxinpsychiatric disturbancesquality of life |
| spellingShingle | Heqing Zheng Lanxiang Wu Sheng Tian Mingxu Liu Qingqing Zhan Xinping Yu Yonggang Xie Xianhui Zhong Wei Wu Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome Frontiers in Neurology Meige syndrome non-motor symptoms botulinum toxin psychiatric disturbances quality of life |
| title | Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome |
| title_full | Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome |
| title_fullStr | Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome |
| title_full_unstemmed | Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome |
| title_short | Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome |
| title_sort | effect of botulinum toxin type a on non motor symptoms and quality of life in meige syndrome |
| topic | Meige syndrome non-motor symptoms botulinum toxin psychiatric disturbances quality of life |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1115482/full |
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