Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials
Poly(ethylene terephthalate)—PET—is one of the most frequently used polymers in biomedical applications. Due to chemical inertness, PET surface modification is necessary to gain specific properties, making the polymer biocompatible. The aim of this paper is to characterize the multi-component films...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/5/2375 |
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| author | Klaudia Szafran Małgorzata Jurak Robert Mroczka Agnieszka Ewa Wiącek |
| author_facet | Klaudia Szafran Małgorzata Jurak Robert Mroczka Agnieszka Ewa Wiącek |
| author_sort | Klaudia Szafran |
| collection | DOAJ |
| description | Poly(ethylene terephthalate)—PET—is one of the most frequently used polymers in biomedical applications. Due to chemical inertness, PET surface modification is necessary to gain specific properties, making the polymer biocompatible. The aim of this paper is to characterize the multi-component films containing chitosan (Ch), phospholipid 1,2-dioleoyl-<i>sn</i>-glycero-3-phosphocholine (DOPC), immunosuppressant cyclosporine A (CsA) and/or antioxidant lauryl gallate (LG) which can be utilized as a very attractive material for developing the PET coatings. Chitosan was employed owing to its antibacterial activity and also its ability to promote cell adhesion and proliferation favorable for tissue engineering and regeneration purposes. Moreover, the Ch film can be additionally modified with other substances of biological importance (DOPC, CsA and LG). The layers of varying compositions were prepared using the Langmuir—Blodgett (LB) technique on the air plasma-activated PET support. Then their nanostructure, molecular distribution, surface chemistry and wettability were determined by atomic force microscopy (AFM), time-of-flight secondary ion mass spectrometry (TOF-SIMS), X-ray photoelectron spectroscopy (XPS), contact angle (CA) measurements and the surface free energy and its components’ determination, respectively. The obtained results show clearly the dependence of the surface properties of the films on the molar ratio of components and allow for a better understanding of the coating organization and mechanisms of interactions at the molecular level both inside the films and between the films and the polar/apolar liquids imitating the environment of different properties. The organized layers of this type can be helpful in gaining control over the surface properties of the biomaterial, thus getting rid of the limitations in favor of increased biocompatibility. This is a good basis for further investigations on the correlation of the immune system response to the presence of biomaterial and its physicochemical properties. |
| first_indexed | 2024-03-11T07:16:34Z |
| format | Article |
| id | doaj.art-6ab1ba4b2cbc44599dbdc52236de3247 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:16:34Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6ab1ba4b2cbc44599dbdc52236de32472023-11-17T08:15:50ZengMDPI AGMolecules1420-30492023-03-01285237510.3390/molecules28052375Preparation and Surface Characterization of Chitosan-Based Coatings for PET MaterialsKlaudia Szafran0Małgorzata Jurak1Robert Mroczka2Agnieszka Ewa Wiącek3Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20031 Lublin, PolandDepartment of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20031 Lublin, PolandLaboratory of X-ray Optics, Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, 20708 Lublin, PolandDepartment of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20031 Lublin, PolandPoly(ethylene terephthalate)—PET—is one of the most frequently used polymers in biomedical applications. Due to chemical inertness, PET surface modification is necessary to gain specific properties, making the polymer biocompatible. The aim of this paper is to characterize the multi-component films containing chitosan (Ch), phospholipid 1,2-dioleoyl-<i>sn</i>-glycero-3-phosphocholine (DOPC), immunosuppressant cyclosporine A (CsA) and/or antioxidant lauryl gallate (LG) which can be utilized as a very attractive material for developing the PET coatings. Chitosan was employed owing to its antibacterial activity and also its ability to promote cell adhesion and proliferation favorable for tissue engineering and regeneration purposes. Moreover, the Ch film can be additionally modified with other substances of biological importance (DOPC, CsA and LG). The layers of varying compositions were prepared using the Langmuir—Blodgett (LB) technique on the air plasma-activated PET support. Then their nanostructure, molecular distribution, surface chemistry and wettability were determined by atomic force microscopy (AFM), time-of-flight secondary ion mass spectrometry (TOF-SIMS), X-ray photoelectron spectroscopy (XPS), contact angle (CA) measurements and the surface free energy and its components’ determination, respectively. The obtained results show clearly the dependence of the surface properties of the films on the molar ratio of components and allow for a better understanding of the coating organization and mechanisms of interactions at the molecular level both inside the films and between the films and the polar/apolar liquids imitating the environment of different properties. The organized layers of this type can be helpful in gaining control over the surface properties of the biomaterial, thus getting rid of the limitations in favor of increased biocompatibility. This is a good basis for further investigations on the correlation of the immune system response to the presence of biomaterial and its physicochemical properties.https://www.mdpi.com/1420-3049/28/5/2375chitosancyclosporine Alauryl gallateXPSAFMTOF-SIMS |
| spellingShingle | Klaudia Szafran Małgorzata Jurak Robert Mroczka Agnieszka Ewa Wiącek Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials Molecules chitosan cyclosporine A lauryl gallate XPS AFM TOF-SIMS |
| title | Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials |
| title_full | Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials |
| title_fullStr | Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials |
| title_full_unstemmed | Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials |
| title_short | Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials |
| title_sort | preparation and surface characterization of chitosan based coatings for pet materials |
| topic | chitosan cyclosporine A lauryl gallate XPS AFM TOF-SIMS |
| url | https://www.mdpi.com/1420-3049/28/5/2375 |
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