Association of p21 SNPs and risk of cervical cancer among Chinese women
<p>Abstract</p> <p>Background</p> <p>The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and other untested p21 SNPs...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/12/589 |
| _version_ | 1811259852633145344 |
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| author | Wang Ning Wang Shizhuo Zhang Qiao Lu Yanming Wei Heng Li Wei Zhang Shulan Yin Duo Ou Yangling |
| author_facet | Wang Ning Wang Shizhuo Zhang Qiao Lu Yanming Wei Heng Li Wei Zhang Shulan Yin Duo Ou Yangling |
| author_sort | Wang Ning |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and other untested p21 SNPs in the risk of cervical cancer in a Chinese population.</p> <p>Methods</p> <p>We genotyped five p21 SNPs (rs762623, rs2395655, rs1801270, rs3176352, and rs1059234) using peripheral blood DNA from 393 cervical cancer patients and 434 controls.</p> <p>Results</p> <p>The frequency of the rs1801270 A allele in patients (0.421) was significantly lower than that in controls (0.494, p = 0.003). The frequency of the rs3176352 C allele in cases (0.319) was significantly lower than that in controls (0.417, p < 0.001).The allele frequency of other three p21 SNPs showed not statistically significantly different between patients and controls. The rs1801270 AA genotype was associated with a decreased risk for the development of cervical cancer (OR = 0.583, 95%CI: 0.399 - 0.853, P = 0.005). We observed that the three p21 SNPs (rs1801270, rs3176352, and rs1059234) was in linkage disequilibrium (LD) and thus haplotype analysis was performed. The AGT haplotype (which includes the rs1801270A allele) was the most frequent haplotype among all subjects, and both homozygosity and heterozygosity for the AGT haplotype provided a protective effect from development of cervical cancer.</p> <p>Conclusions</p> <p>We show an association between the p21 SNP rs1801270A allele and a decreased risk for cervical cancer in a population of Chinese women. The AGT haplotype formed by three p21 SNPs in LD (rs1801270, rs3176352 and rs1059234) also provided a protective effect in development of cervical cancer in this population.</p> |
| first_indexed | 2024-04-12T18:37:54Z |
| format | Article |
| id | doaj.art-6ab21b2cb23747a28225b6b384a6828b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T18:37:54Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj.art-6ab21b2cb23747a28225b6b384a6828b2022-12-22T03:20:53ZengBMCBMC Cancer1471-24072012-12-0112158910.1186/1471-2407-12-589Association of p21 SNPs and risk of cervical cancer among Chinese womenWang NingWang ShizhuoZhang QiaoLu YanmingWei HengLi WeiZhang ShulanYin DuoOu Yangling<p>Abstract</p> <p>Background</p> <p>The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results. The aims of this study were to investigate the role of p21 SNP-rs1801270 and other untested p21 SNPs in the risk of cervical cancer in a Chinese population.</p> <p>Methods</p> <p>We genotyped five p21 SNPs (rs762623, rs2395655, rs1801270, rs3176352, and rs1059234) using peripheral blood DNA from 393 cervical cancer patients and 434 controls.</p> <p>Results</p> <p>The frequency of the rs1801270 A allele in patients (0.421) was significantly lower than that in controls (0.494, p = 0.003). The frequency of the rs3176352 C allele in cases (0.319) was significantly lower than that in controls (0.417, p < 0.001).The allele frequency of other three p21 SNPs showed not statistically significantly different between patients and controls. The rs1801270 AA genotype was associated with a decreased risk for the development of cervical cancer (OR = 0.583, 95%CI: 0.399 - 0.853, P = 0.005). We observed that the three p21 SNPs (rs1801270, rs3176352, and rs1059234) was in linkage disequilibrium (LD) and thus haplotype analysis was performed. The AGT haplotype (which includes the rs1801270A allele) was the most frequent haplotype among all subjects, and both homozygosity and heterozygosity for the AGT haplotype provided a protective effect from development of cervical cancer.</p> <p>Conclusions</p> <p>We show an association between the p21 SNP rs1801270A allele and a decreased risk for cervical cancer in a population of Chinese women. The AGT haplotype formed by three p21 SNPs in LD (rs1801270, rs3176352 and rs1059234) also provided a protective effect in development of cervical cancer in this population.</p>http://www.biomedcentral.com/1471-2407/12/589P21Single nucleotide polymorphismCervical cancerHaplotype |
| spellingShingle | Wang Ning Wang Shizhuo Zhang Qiao Lu Yanming Wei Heng Li Wei Zhang Shulan Yin Duo Ou Yangling Association of p21 SNPs and risk of cervical cancer among Chinese women BMC Cancer P21 Single nucleotide polymorphism Cervical cancer Haplotype |
| title | Association of p21 SNPs and risk of cervical cancer among Chinese women |
| title_full | Association of p21 SNPs and risk of cervical cancer among Chinese women |
| title_fullStr | Association of p21 SNPs and risk of cervical cancer among Chinese women |
| title_full_unstemmed | Association of p21 SNPs and risk of cervical cancer among Chinese women |
| title_short | Association of p21 SNPs and risk of cervical cancer among Chinese women |
| title_sort | association of p21 snps and risk of cervical cancer among chinese women |
| topic | P21 Single nucleotide polymorphism Cervical cancer Haplotype |
| url | http://www.biomedcentral.com/1471-2407/12/589 |
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