Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD)
Background. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2022-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/9656278 |
| _version_ | 1827000608406634496 |
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| author | Jia-Ying Luo Hui-An Chen Yuan-Yu Feng Ye-Peng Chen Xiang-Cheng Lei Shuang-Lin Guo Xiao-Bin Huang Zhi-Man Liang Ning Li Bao-Qing Sun |
| author_facet | Jia-Ying Luo Hui-An Chen Yuan-Yu Feng Ye-Peng Chen Xiang-Cheng Lei Shuang-Lin Guo Xiao-Bin Huang Zhi-Man Liang Ning Li Bao-Qing Sun |
| author_sort | Jia-Ying Luo |
| collection | DOAJ |
| description | Background. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences of blood eosinophil counts between asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO). Methods. Patients with asthma, COPD, and ACO who were seen in the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2019 were included. We collected information such as age, gender, diagnosis, the eosinophil counts from the medical records. Moreover, the levels of 10 cytokines in the plasma of each group were detected by using the Meso Scale Discovery method. Results. We included 9787 patients with asthma, 15806 patients with COPD, and 831 ACO patients. From our results, it can be first found that eosinophil levels were age-related in the three diseases (asthma and ACO: p<0.001; COPD: P=0.001); in asthma and COPD, the number of eosinophils in males was more significant than that in females (asthma: p<0.001; COPD: p=0.012). Second, asthma patients had higher blood eosinophil counts than those with COPD and ACO (p<0.001). Moreover, we found out that eosinophil levels were highly expressed in the stable group of all three diseases. Finally, we found that most cytokines in ACO patients showed a downward trend when the level of eosinophils was low, whereas the results were reversed in asthma patients; 7 cytokines had similar trends in COPD and ACO patients. Conclusions. In conclusion, eosinophils have their own unique endotypes in asthma, COPD, and ACO patients, which were reflected in the fluctuation of their levels and changes in cytokine secretion. |
| first_indexed | 2024-04-11T08:53:56Z |
| format | Article |
| id | doaj.art-6ab24d5812c24cc4a5c531110427780c |
| institution | Directory Open Access Journal |
| issn | 1916-7245 |
| language | English |
| last_indexed | 2025-02-18T10:47:51Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj.art-6ab24d5812c24cc4a5c531110427780c2024-11-02T05:27:07ZengHindawi LimitedCanadian Respiratory Journal1916-72452022-01-01202210.1155/2022/9656278Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD)Jia-Ying Luo0Hui-An Chen1Yuan-Yu Feng2Ye-Peng Chen3Xiang-Cheng Lei4Shuang-Lin Guo5Xiao-Bin Huang6Zhi-Man Liang7Ning Li8Bao-Qing Sun9Department of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologGuangzhou Medical UniversityDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologDepartment of Allergy and Clinical ImmunologBackground. Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences of blood eosinophil counts between asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO). Methods. Patients with asthma, COPD, and ACO who were seen in the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2019 were included. We collected information such as age, gender, diagnosis, the eosinophil counts from the medical records. Moreover, the levels of 10 cytokines in the plasma of each group were detected by using the Meso Scale Discovery method. Results. We included 9787 patients with asthma, 15806 patients with COPD, and 831 ACO patients. From our results, it can be first found that eosinophil levels were age-related in the three diseases (asthma and ACO: p<0.001; COPD: P=0.001); in asthma and COPD, the number of eosinophils in males was more significant than that in females (asthma: p<0.001; COPD: p=0.012). Second, asthma patients had higher blood eosinophil counts than those with COPD and ACO (p<0.001). Moreover, we found out that eosinophil levels were highly expressed in the stable group of all three diseases. Finally, we found that most cytokines in ACO patients showed a downward trend when the level of eosinophils was low, whereas the results were reversed in asthma patients; 7 cytokines had similar trends in COPD and ACO patients. Conclusions. In conclusion, eosinophils have their own unique endotypes in asthma, COPD, and ACO patients, which were reflected in the fluctuation of their levels and changes in cytokine secretion.http://dx.doi.org/10.1155/2022/9656278 |
| spellingShingle | Jia-Ying Luo Hui-An Chen Yuan-Yu Feng Ye-Peng Chen Xiang-Cheng Lei Shuang-Lin Guo Xiao-Bin Huang Zhi-Man Liang Ning Li Bao-Qing Sun Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) Canadian Respiratory Journal |
| title | Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| title_full | Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| title_fullStr | Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| title_full_unstemmed | Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| title_short | Blood Eosinophil Endotypes across Asthma and Chronic Obstructive Pulmonary Disease (COPD) |
| title_sort | blood eosinophil endotypes across asthma and chronic obstructive pulmonary disease copd |
| url | http://dx.doi.org/10.1155/2022/9656278 |
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