Overview of Neutralizing Antibodies and Their Potential in COVID-19
The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd imm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/12/1376 |
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| author | José Javier Morales-Núñez José Francisco Muñoz-Valle Paola Carolina Torres-Hernández Jorge Hernández-Bello |
| author_facet | José Javier Morales-Núñez José Francisco Muñoz-Valle Paola Carolina Torres-Hernández Jorge Hernández-Bello |
| author_sort | José Javier Morales-Núñez |
| collection | DOAJ |
| description | The antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd immunity against SARS-CoV-2, vaccine efficacy, and humoral protective response longevity, as well as supporting donor selection criteria for convalescent plasma therapy. In the current manuscript, we review the essential concepts of NAbs, examining their concept, mechanisms of action, production, and the techniques used for their detection; as well as presenting an overview of the clinical use of antibodies in COVID-19. |
| first_indexed | 2024-03-10T03:57:06Z |
| format | Article |
| id | doaj.art-6ab2dec5ee6a4f3d971641e938aee4c5 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T03:57:06Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6ab2dec5ee6a4f3d971641e938aee4c52023-11-23T10:53:28ZengMDPI AGVaccines2076-393X2021-11-01912137610.3390/vaccines9121376Overview of Neutralizing Antibodies and Their Potential in COVID-19José Javier Morales-Núñez0José Francisco Muñoz-Valle1Paola Carolina Torres-Hernández2Jorge Hernández-Bello3Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, MexicoInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, MexicoImmunology Laboratory, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, MexicoInstitute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), University of Guadalajara, Guadalajara 44340, MexicoThe antibody response to respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a major focus of COVID-19 research due to its clinical relevance and importance in vaccine and therapeutic development. Neutralizing antibody (NAb) evaluations are useful for the determination of individual or herd immunity against SARS-CoV-2, vaccine efficacy, and humoral protective response longevity, as well as supporting donor selection criteria for convalescent plasma therapy. In the current manuscript, we review the essential concepts of NAbs, examining their concept, mechanisms of action, production, and the techniques used for their detection; as well as presenting an overview of the clinical use of antibodies in COVID-19.https://www.mdpi.com/2076-393X/9/12/1376neutralizing antibodiesSARS-CoV-2neutralization assaysCOVID-19monoclonal antibodies |
| spellingShingle | José Javier Morales-Núñez José Francisco Muñoz-Valle Paola Carolina Torres-Hernández Jorge Hernández-Bello Overview of Neutralizing Antibodies and Their Potential in COVID-19 Vaccines neutralizing antibodies SARS-CoV-2 neutralization assays COVID-19 monoclonal antibodies |
| title | Overview of Neutralizing Antibodies and Their Potential in COVID-19 |
| title_full | Overview of Neutralizing Antibodies and Their Potential in COVID-19 |
| title_fullStr | Overview of Neutralizing Antibodies and Their Potential in COVID-19 |
| title_full_unstemmed | Overview of Neutralizing Antibodies and Their Potential in COVID-19 |
| title_short | Overview of Neutralizing Antibodies and Their Potential in COVID-19 |
| title_sort | overview of neutralizing antibodies and their potential in covid 19 |
| topic | neutralizing antibodies SARS-CoV-2 neutralization assays COVID-19 monoclonal antibodies |
| url | https://www.mdpi.com/2076-393X/9/12/1376 |
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