Twisting and extension: Application of magnetic tweezers to DNA studies
Magnetic tweezers have emerged as a vital force spectroscopy tool for characterizing the mechanical properties of nucleic acids and their interactions with proteins. Harnessing the principles of magnetic theory, magnetic tweezers allow for the precise manipulation of biological compounds at the sing...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2023-09-01
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| Series: | AIMS Biophysics |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/biophy.2023020?viewType=HTML |
| _version_ | 1797657807589212160 |
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| author | Arsha Moorthy Alireza Sarvestani Whitney Massock Chamaree de Silva |
| author_facet | Arsha Moorthy Alireza Sarvestani Whitney Massock Chamaree de Silva |
| author_sort | Arsha Moorthy |
| collection | DOAJ |
| description | Magnetic tweezers have emerged as a vital force spectroscopy tool for characterizing the mechanical properties of nucleic acids and their interactions with proteins. Harnessing the principles of magnetic theory, magnetic tweezers allow for the precise manipulation of biological compounds at the single-molecule level through the imposition of a magnetic field. This review focuses on the application of magnetic tweezers in the context of DNA studies, with a particular emphasis on the mechanical properties of DNA and its dynamic interactions with proteins and enzymes. These interactions are essential to genomic transactions such as DNA replication, repair, and transcription. Over the last few decades, magnetic tweezer technology has experienced significant advancements, leading to the development of different types of magnetic tweezers. These technological breakthroughs have opened up new avenues of scientific research, including studies related to DNA elasticity, supercoiling, replication, and repair. |
| first_indexed | 2024-03-11T17:50:03Z |
| format | Article |
| id | doaj.art-6ab38078dc854a308694b196553b06d4 |
| institution | Directory Open Access Journal |
| issn | 2377-9098 |
| language | English |
| last_indexed | 2024-03-11T17:50:03Z |
| publishDate | 2023-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Biophysics |
| spelling | doaj.art-6ab38078dc854a308694b196553b06d42023-10-18T06:38:20ZengAIMS PressAIMS Biophysics2377-90982023-09-0110331734610.3934/biophy.2023020Twisting and extension: Application of magnetic tweezers to DNA studiesArsha Moorthy 0Alireza Sarvestani1Whitney Massock2Chamaree de Silva31. College of Liberal Arts and Sciences, Mercer University, Macon, GA 31207, USA2. School of Engineering, Mercer University, Macon, GA 31207, USA1. College of Liberal Arts and Sciences, Mercer University, Macon, GA 31207, USA1. College of Liberal Arts and Sciences, Mercer University, Macon, GA 31207, USAMagnetic tweezers have emerged as a vital force spectroscopy tool for characterizing the mechanical properties of nucleic acids and their interactions with proteins. Harnessing the principles of magnetic theory, magnetic tweezers allow for the precise manipulation of biological compounds at the single-molecule level through the imposition of a magnetic field. This review focuses on the application of magnetic tweezers in the context of DNA studies, with a particular emphasis on the mechanical properties of DNA and its dynamic interactions with proteins and enzymes. These interactions are essential to genomic transactions such as DNA replication, repair, and transcription. Over the last few decades, magnetic tweezer technology has experienced significant advancements, leading to the development of different types of magnetic tweezers. These technological breakthroughs have opened up new avenues of scientific research, including studies related to DNA elasticity, supercoiling, replication, and repair.https://www.aimspress.com/article/doi/10.3934/biophy.2023020?viewType=HTMLmagnetic tweezersdnamagnetic theorydna supercoilingdna transcriptiondna replicationforce spectroscopy |
| spellingShingle | Arsha Moorthy Alireza Sarvestani Whitney Massock Chamaree de Silva Twisting and extension: Application of magnetic tweezers to DNA studies AIMS Biophysics magnetic tweezers dna magnetic theory dna supercoiling dna transcription dna replication force spectroscopy |
| title | Twisting and extension: Application of magnetic tweezers to DNA studies |
| title_full | Twisting and extension: Application of magnetic tweezers to DNA studies |
| title_fullStr | Twisting and extension: Application of magnetic tweezers to DNA studies |
| title_full_unstemmed | Twisting and extension: Application of magnetic tweezers to DNA studies |
| title_short | Twisting and extension: Application of magnetic tweezers to DNA studies |
| title_sort | twisting and extension application of magnetic tweezers to dna studies |
| topic | magnetic tweezers dna magnetic theory dna supercoiling dna transcription dna replication force spectroscopy |
| url | https://www.aimspress.com/article/doi/10.3934/biophy.2023020?viewType=HTML |
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