Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India
Background: Despite being given the best by the health department to eradicate the disease, an alarming rise of tuberculosis (TB) remains a significant public health concern in India. Recently, highly variable clinical manifestations of TB have been reported. This study highlights the unusual presen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2022;volume=11;issue=1;spage=30;epage=37;aulast=Singh |
| _version_ | 1798021853472620544 |
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| author | Jitendra Singh Anju Dinkar Poonam Gupta |
| author_facet | Jitendra Singh Anju Dinkar Poonam Gupta |
| author_sort | Jitendra Singh |
| collection | DOAJ |
| description | Background: Despite being given the best by the health department to eradicate the disease, an alarming rise of tuberculosis (TB) remains a significant public health concern in India. Recently, highly variable clinical manifestations of TB have been reported. This study highlights the unusual presentations of TB with a comprehensive overview of epidemiology, demography and risk factors in the expended clinical spectrum of TB patients and their outcomes. Methods: It is a retrospective study using the records of 503 TB patients of all age groups of either sex from July 2017 to January 2021 at two tertiary care hospitals in North India. Results: Out of 503 cases, pulmonary, extrapulmonary, and disseminated TB were 77.7%, 19.5%, and 2.8%, respectively. Among all TB cases, 36 (7.2%) had uncommon manifestations, including the most common was pyrexia of unknown origin in 12 (33.3%) cases and liver abscess in 5 (13.9%) cases, followed by pancytopenia in 4 (11.1%) cases and chyluria in 3 (8.3%) cases. Atypical skin nodules and multiple swellings were also noted in three (8.3%) cases. Male sex (58%) and rural area (66.7%) were dominant in TB with uncommon manifestation (TBU) cases. The mean age in TBU cases was 46.92 years, whereas 34.26 years in all TB cases. It was extremely significant. The statistically significant risk factors in the TBU case were low socioeconomic status (24, 66.7%), inadequate nutrition (11, 30.6%), and smoking (19, 52.8%). Conclusions: Early recognition of uncommon presentations is imperative to respond better. |
| first_indexed | 2024-04-11T17:20:10Z |
| format | Article |
| id | doaj.art-6ab46cf7257b47eb8a9b803fcc0816dc |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-04-11T17:20:10Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-6ab46cf7257b47eb8a9b803fcc0816dc2022-12-22T04:12:30ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2022-01-01111303710.4103/ijmy.ijmy_242_21Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North IndiaJitendra SinghAnju DinkarPoonam GuptaBackground: Despite being given the best by the health department to eradicate the disease, an alarming rise of tuberculosis (TB) remains a significant public health concern in India. Recently, highly variable clinical manifestations of TB have been reported. This study highlights the unusual presentations of TB with a comprehensive overview of epidemiology, demography and risk factors in the expended clinical spectrum of TB patients and their outcomes. Methods: It is a retrospective study using the records of 503 TB patients of all age groups of either sex from July 2017 to January 2021 at two tertiary care hospitals in North India. Results: Out of 503 cases, pulmonary, extrapulmonary, and disseminated TB were 77.7%, 19.5%, and 2.8%, respectively. Among all TB cases, 36 (7.2%) had uncommon manifestations, including the most common was pyrexia of unknown origin in 12 (33.3%) cases and liver abscess in 5 (13.9%) cases, followed by pancytopenia in 4 (11.1%) cases and chyluria in 3 (8.3%) cases. Atypical skin nodules and multiple swellings were also noted in three (8.3%) cases. Male sex (58%) and rural area (66.7%) were dominant in TB with uncommon manifestation (TBU) cases. The mean age in TBU cases was 46.92 years, whereas 34.26 years in all TB cases. It was extremely significant. The statistically significant risk factors in the TBU case were low socioeconomic status (24, 66.7%), inadequate nutrition (11, 30.6%), and smoking (19, 52.8%). Conclusions: Early recognition of uncommon presentations is imperative to respond better.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2022;volume=11;issue=1;spage=30;epage=37;aulast=Singhatypical presentationdisseminated tuberculosisextrapulmonary tuberculosismultidrug-resistant tuberculosispancytopeniapyrexia of unknown origin |
| spellingShingle | Jitendra Singh Anju Dinkar Poonam Gupta Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India International Journal of Mycobacteriology atypical presentation disseminated tuberculosis extrapulmonary tuberculosis multidrug-resistant tuberculosis pancytopenia pyrexia of unknown origin |
| title | Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India |
| title_full | Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India |
| title_fullStr | Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India |
| title_full_unstemmed | Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India |
| title_short | Uncommon manifestations in tuberculosis: An expanding clinical spectrum from North India |
| title_sort | uncommon manifestations in tuberculosis an expanding clinical spectrum from north india |
| topic | atypical presentation disseminated tuberculosis extrapulmonary tuberculosis multidrug-resistant tuberculosis pancytopenia pyrexia of unknown origin |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2022;volume=11;issue=1;spage=30;epage=37;aulast=Singh |
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