The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates
Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (<i>n</i> = 13) and health...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/10/8496 |
| _version_ | 1797599877680594944 |
|---|---|
| author | Barbara Sandor Beata Csiszar Gergely Galos Simone Funke Dora Kinga Kevey Matyas Meggyes Laszlo Szereday Kalman Toth |
| author_facet | Barbara Sandor Beata Csiszar Gergely Galos Simone Funke Dora Kinga Kevey Matyas Meggyes Laszlo Szereday Kalman Toth |
| author_sort | Barbara Sandor |
| collection | DOAJ |
| description | Preeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (<i>n</i> = 13) and healthy neonates (<i>n</i> = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia. |
| first_indexed | 2024-03-11T03:40:33Z |
| format | Article |
| id | doaj.art-6ab54ea058994999bfd13f373a646a8d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:40:33Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6ab54ea058994999bfd13f373a646a8d2023-11-18T01:36:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410849610.3390/ijms24108496The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of NeonatesBarbara Sandor0Beata Csiszar1Gergely Galos2Simone Funke3Dora Kinga Kevey4Matyas Meggyes5Laszlo Szereday6Kalman Toth71st Department of Medicine, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Anaesthesiology and Intensive Therapy, Medical School, University of Pécs, 7624 Pécs, Hungary1st Department of Medicine, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Obstetrics and Gynaecology, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, 7624 Pécs, Hungary1st Department of Medicine, Medical School, University of Pécs, 7624 Pécs, HungaryPreeclampsia is the leading cause of complicated neonatal adaptation. The present investigation aimed to study the hemorheological factors during the early perinatal period (cord blood, 24 and 72 h after delivery) in newborns of early-onset preeclamptic mothers (<i>n</i> = 13) and healthy neonates (<i>n</i> = 17). Hematocrit, plasma, and whole blood viscosity (WBV), red blood cell (RBC) aggregation, and deformability were investigated. There were no significant differences in hematocrit. WBV was significantly lower in preterm neonates at birth than in the term 24 and 72 h samples. Plasma viscosity was significantly lower in preterm neonates’ cord blood than in healthy controls. RBC aggregation parameters were significantly lower in preterm newborns’ cord blood than in term neonates’ cord blood 24 and 72 h samples. RBC elongation indices were significantly lower in the term group than in preterm neonates 72 h’ sample at the high and middle shear stress range. Changes in the hemorheological parameters, especially RBC aggregation properties, refer to better microcirculation of preterm neonates at birth, which could be an adaptation mechanism to the impaired uteroplacental microcirculation in preeclampsia.https://www.mdpi.com/1422-0067/24/10/8496preeclampsiared blood cell propertiesneonatal adaptationintrauterine growth restriction |
| spellingShingle | Barbara Sandor Beata Csiszar Gergely Galos Simone Funke Dora Kinga Kevey Matyas Meggyes Laszlo Szereday Kalman Toth The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates International Journal of Molecular Sciences preeclampsia red blood cell properties neonatal adaptation intrauterine growth restriction |
| title | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
| title_full | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
| title_fullStr | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
| title_full_unstemmed | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
| title_short | The Influence of Early Onset Preeclampsia on Perinatal Red Blood Cell Characteristics of Neonates |
| title_sort | influence of early onset preeclampsia on perinatal red blood cell characteristics of neonates |
| topic | preeclampsia red blood cell properties neonatal adaptation intrauterine growth restriction |
| url | https://www.mdpi.com/1422-0067/24/10/8496 |
| work_keys_str_mv | AT barbarasandor theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT beatacsiszar theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT gergelygalos theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT simonefunke theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT dorakingakevey theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT matyasmeggyes theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT laszloszereday theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT kalmantoth theinfluenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT barbarasandor influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT beatacsiszar influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT gergelygalos influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT simonefunke influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT dorakingakevey influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT matyasmeggyes influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT laszloszereday influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates AT kalmantoth influenceofearlyonsetpreeclampsiaonperinatalredbloodcellcharacteristicsofneonates |