Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche
Cancer-induced bone pain is the most common complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (osteoclasts, osteoblasts, macrophages, mast...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Publiediting
2019-01-01
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| Series: | Pathos |
| Subjects: | |
| Online Access: | https://www.pathos-journal.com/2019_1_193.html |
| _version_ | 1818343931999420416 |
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| author | Francesco Amato Erminia Gilda Morrone |
| author_facet | Francesco Amato Erminia Gilda Morrone |
| author_sort | Francesco Amato |
| collection | DOAJ |
| description | Cancer-induced bone pain is the most common complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (osteoclasts, osteoblasts, macrophages, mast cells, mesenchymal stem cells and fibroblasts) in bone pain metastases development. Available analgesic treatments for bone pain metastases, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments are needed to develop more effective and safer targeted therapies. |
| first_indexed | 2024-12-13T16:38:26Z |
| format | Article |
| id | doaj.art-6ab57556f9704fab91d2dc6006642eca |
| institution | Directory Open Access Journal |
| issn | 1593-2354 2385-0744 |
| language | English |
| last_indexed | 2024-12-13T16:38:26Z |
| publishDate | 2019-01-01 |
| publisher | Publiediting |
| record_format | Article |
| series | Pathos |
| spelling | doaj.art-6ab57556f9704fab91d2dc6006642eca2022-12-21T23:38:21ZengPublieditingPathos1593-23542385-07442019-01-01261Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeuticheFrancesco Amato0Erminia Gilda Morrone1Direttore UOC Terapia del Dolore e CP Azienda Ospedaliera Cosenza, Centro Hub RegionaleBiologa, Associazione Centro Studi Terapia del Dolore, CosenzaCancer-induced bone pain is the most common complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (osteoclasts, osteoblasts, macrophages, mast cells, mesenchymal stem cells and fibroblasts) in bone pain metastases development. Available analgesic treatments for bone pain metastases, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments are needed to develop more effective and safer targeted therapies.https://www.pathos-journal.com/2019_1_193.htmlCancer-induced bone painbone marrow microenvironmentbone metastasesosteoclastsmacrophages |
| spellingShingle | Francesco Amato Erminia Gilda Morrone Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche Pathos Cancer-induced bone pain bone marrow microenvironment bone metastases osteoclasts macrophages |
| title | Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche |
| title_full | Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche |
| title_fullStr | Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche |
| title_full_unstemmed | Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche |
| title_short | Pain in bone metastases: from physiopathology to therapeutic options - Il dolore nelle metastasi ossee: dalla fisiopatologia alle opzioni terapeutiche |
| title_sort | pain in bone metastases from physiopathology to therapeutic options il dolore nelle metastasi ossee dalla fisiopatologia alle opzioni terapeutiche |
| topic | Cancer-induced bone pain bone marrow microenvironment bone metastases osteoclasts macrophages |
| url | https://www.pathos-journal.com/2019_1_193.html |
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