Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections
Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel d...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/9/1208 |
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| author | Elham Zarenezhad Hussein T. Abdulabbas Mahrokh Marzi Esraa Ghazy Mohammad Ekrahi Babak Pezeshki Abdolmajid Ghasemian Amira A. Moawad |
| author_facet | Elham Zarenezhad Hussein T. Abdulabbas Mahrokh Marzi Esraa Ghazy Mohammad Ekrahi Babak Pezeshki Abdolmajid Ghasemian Amira A. Moawad |
| author_sort | Elham Zarenezhad |
| collection | DOAJ |
| description | Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes. |
| first_indexed | 2024-03-10T00:54:48Z |
| format | Article |
| id | doaj.art-6ab6d1c3afca4cb681826fdca8718cb5 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T00:54:48Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-6ab6d1c3afca4cb681826fdca8718cb52023-11-23T14:44:51ZengMDPI AGAntibiotics2079-63822022-09-01119120810.3390/antibiotics11091208Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> InfectionsElham Zarenezhad0Hussein T. Abdulabbas1Mahrokh Marzi2Esraa Ghazy3Mohammad Ekrahi4Babak Pezeshki5Abdolmajid Ghasemian6Amira A. Moawad7Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, IranDepartment of Medical Laboratory Techniques, Faculty of Health and Medical Techniques, Imam Ja’afar Al-Sadiq University, Al Muthanna 9647555434, IraqNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, IranDepartment of pharmacy, Al-Rasheed University College, Baghdad 9643675544, IraqNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, IranNoncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, IranFriedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743 Jena, GermanyMethicillin-resistant <i>Staphylococcus aureus</i> (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes.https://www.mdpi.com/2079-6382/11/9/1208methicillin-resistant <i>Staphylococcus aureus</i>nickel nanoparticlesantibacterial effects |
| spellingShingle | Elham Zarenezhad Hussein T. Abdulabbas Mahrokh Marzi Esraa Ghazy Mohammad Ekrahi Babak Pezeshki Abdolmajid Ghasemian Amira A. Moawad Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections Antibiotics methicillin-resistant <i>Staphylococcus aureus</i> nickel nanoparticles antibacterial effects |
| title | Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections |
| title_full | Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections |
| title_fullStr | Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections |
| title_full_unstemmed | Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections |
| title_short | Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant <i>Staphylococcus aureus</i> Infections |
| title_sort | nickel nanoparticles applications and antimicrobial role against methicillin resistant i staphylococcus aureus i infections |
| topic | methicillin-resistant <i>Staphylococcus aureus</i> nickel nanoparticles antibacterial effects |
| url | https://www.mdpi.com/2079-6382/11/9/1208 |
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