Research progress on effects of air pollution on pollinosis and its mechanisms
Pollinosis is one of the common allergic diseases, and its morbidity continues to increase. Studies have demonstrated that air pollution is a key environmental factor that leads to the increased prevalence of pollinosis. Air pollutants and pollen allergens exert synergistic effects in stimulating al...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2024-01-01
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| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM23232 |
| _version_ | 1797337224186953728 |
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| author | Qi LU Yue WU Qihang ZHANG Shan DENG |
| author_facet | Qi LU Yue WU Qihang ZHANG Shan DENG |
| author_sort | Qi LU |
| collection | DOAJ |
| description | Pollinosis is one of the common allergic diseases, and its morbidity continues to increase. Studies have demonstrated that air pollution is a key environmental factor that leads to the increased prevalence of pollinosis. Air pollutants and pollen allergens exert synergistic effects in stimulating allergic responses in susceptible individuals. In this article, we analyzed the relationship between air pollution and pollinosis based on the latest studies, and elaborated potential mechanisms on how air pollution increases the incidence of pollinosis and aggravates allergic reactions. Air pollutants can increase both pollen production and the levels of allergenic proteins, and enhance allergenicity of pollen allergens through structural alterations or chemical modifications. The potential mechanisms of air pollutants exacerbating pollen allergies are as follows: Air pollutants may disrupt the barrier function of the respiratory epithelium and facilitate the penetration of pollen allergens into deeper tissues. Additionally, they may accelerate the process of the release of pollen allergy-related cytokines, promoting T helper 2 (Th2) cell differentiation and exacerbating inflammatory responses in the airways. Given the limitations of existing research, future prospective studies are needed to explore the effects of mixed pollutants and different types of pollutants on pollen, and the response mechanisms of allergy-related cells and cytokines to different pollutant categories. The findings would provide a comprehensive understanding of the impacts of air pollution on pollen allergies and scientific evidence for effective protection of the heath of pollinosis patients. |
| first_indexed | 2024-03-08T09:06:24Z |
| format | Article |
| id | doaj.art-6ab8ce0b6fcf48ac8c03c0da432e8467 |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-03-08T09:06:24Z |
| publishDate | 2024-01-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-6ab8ce0b6fcf48ac8c03c0da432e84672024-02-01T05:11:47ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822024-01-0141110310910.11836/JEOM2323223232Research progress on effects of air pollution on pollinosis and its mechanismsQi LU0Yue WU1Qihang ZHANG2Shan DENG3Department of Allergy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, ChinaDepartment of Allergy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, ChinaDepartment of Allergy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, ChinaDepartment of Allergy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, ChinaPollinosis is one of the common allergic diseases, and its morbidity continues to increase. Studies have demonstrated that air pollution is a key environmental factor that leads to the increased prevalence of pollinosis. Air pollutants and pollen allergens exert synergistic effects in stimulating allergic responses in susceptible individuals. In this article, we analyzed the relationship between air pollution and pollinosis based on the latest studies, and elaborated potential mechanisms on how air pollution increases the incidence of pollinosis and aggravates allergic reactions. Air pollutants can increase both pollen production and the levels of allergenic proteins, and enhance allergenicity of pollen allergens through structural alterations or chemical modifications. The potential mechanisms of air pollutants exacerbating pollen allergies are as follows: Air pollutants may disrupt the barrier function of the respiratory epithelium and facilitate the penetration of pollen allergens into deeper tissues. Additionally, they may accelerate the process of the release of pollen allergy-related cytokines, promoting T helper 2 (Th2) cell differentiation and exacerbating inflammatory responses in the airways. Given the limitations of existing research, future prospective studies are needed to explore the effects of mixed pollutants and different types of pollutants on pollen, and the response mechanisms of allergy-related cells and cytokines to different pollutant categories. The findings would provide a comprehensive understanding of the impacts of air pollution on pollen allergies and scientific evidence for effective protection of the heath of pollinosis patients.http://www.jeom.org/article/cn/10.11836/JEOM23232air pollutionpollinosisallergyallergenic proteinallergenicitymechanism |
| spellingShingle | Qi LU Yue WU Qihang ZHANG Shan DENG Research progress on effects of air pollution on pollinosis and its mechanisms 环境与职业医学 air pollution pollinosis allergy allergenic protein allergenicity mechanism |
| title | Research progress on effects of air pollution on pollinosis and its mechanisms |
| title_full | Research progress on effects of air pollution on pollinosis and its mechanisms |
| title_fullStr | Research progress on effects of air pollution on pollinosis and its mechanisms |
| title_full_unstemmed | Research progress on effects of air pollution on pollinosis and its mechanisms |
| title_short | Research progress on effects of air pollution on pollinosis and its mechanisms |
| title_sort | research progress on effects of air pollution on pollinosis and its mechanisms |
| topic | air pollution pollinosis allergy allergenic protein allergenicity mechanism |
| url | http://www.jeom.org/article/cn/10.11836/JEOM23232 |
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