Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics
Objective: To observe the effect of Danhong injection (DHI) on perioperative metabolomics of unstable angina pectoris (UA) with blood stasis syndrome. Materials and Methods: A prospective, randomized, controlled, and single-blind clinical trial was conducted. Sixty-one UA patients with traditional C...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | World Journal of Traditional Chinese Medicine |
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| Online Access: | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2022;volume=8;issue=2;spage=247;epage=256;aulast=Niu |
| _version_ | 1818479114415243264 |
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| author | Qian Niu Wen-Long Xing Yu-Tong Wang Yan Zhu Hong-Xu Liu |
| author_facet | Qian Niu Wen-Long Xing Yu-Tong Wang Yan Zhu Hong-Xu Liu |
| author_sort | Qian Niu |
| collection | DOAJ |
| description | Objective: To observe the effect of Danhong injection (DHI) on perioperative metabolomics of unstable angina pectoris (UA) with blood stasis syndrome. Materials and Methods: A prospective, randomized, controlled, and single-blind clinical trial was conducted. Sixty-one UA patients with traditional Chinese medicine blood stasis syndrome undergoing elective percutaneous coronary intervention (PCI) were randomly divided into the Danhong and control groups, and 10 healthy volunteers were included as baseline. The Danhong group received western medicine + DHI treatment, while the control group received western medicine + saline. Nontargeted metabolomics was used to analyze the serum metabolites of healthy volunteers in the Danhong and control groups before and 5 days after PCI. Results: Before treatment, there was no significant difference in serum metabolites between the Danhong and control groups, but there was a significant difference between the two groups and the healthy group. Differential metabolites were clustered mainly in glycerophospholipid, sphingolipid, purine, and amino acid groups, which were generated in their metabolic pathways. After 5 days of PCI, the profiles of serum metabolites were significantly closer between the Danhong-or control-treated groups and that of the healthy group. Furthermore, DHI treatment converted the serum metabolite profile more to that of the healthy group than the control treatment. Conclusion: The beneficial effect of DHI on patients with unstable angina is reflected at the level of serum metabolic biomarkers. |
| first_indexed | 2024-12-10T09:56:56Z |
| format | Article |
| id | doaj.art-6ab8e65e9b994a5b881314d0b04fcd1f |
| institution | Directory Open Access Journal |
| issn | 2311-8571 |
| language | English |
| last_indexed | 2024-12-10T09:56:56Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj.art-6ab8e65e9b994a5b881314d0b04fcd1f2022-12-22T01:53:28ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712022-01-018224725610.4103/wjtcm.wjtcm_63_21Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomicsQian NiuWen-Long XingYu-Tong WangYan ZhuHong-Xu LiuObjective: To observe the effect of Danhong injection (DHI) on perioperative metabolomics of unstable angina pectoris (UA) with blood stasis syndrome. Materials and Methods: A prospective, randomized, controlled, and single-blind clinical trial was conducted. Sixty-one UA patients with traditional Chinese medicine blood stasis syndrome undergoing elective percutaneous coronary intervention (PCI) were randomly divided into the Danhong and control groups, and 10 healthy volunteers were included as baseline. The Danhong group received western medicine + DHI treatment, while the control group received western medicine + saline. Nontargeted metabolomics was used to analyze the serum metabolites of healthy volunteers in the Danhong and control groups before and 5 days after PCI. Results: Before treatment, there was no significant difference in serum metabolites between the Danhong and control groups, but there was a significant difference between the two groups and the healthy group. Differential metabolites were clustered mainly in glycerophospholipid, sphingolipid, purine, and amino acid groups, which were generated in their metabolic pathways. After 5 days of PCI, the profiles of serum metabolites were significantly closer between the Danhong-or control-treated groups and that of the healthy group. Furthermore, DHI treatment converted the serum metabolite profile more to that of the healthy group than the control treatment. Conclusion: The beneficial effect of DHI on patients with unstable angina is reflected at the level of serum metabolic biomarkers.http://www.wjtcm.net/article.asp?issn=2311-8571;year=2022;volume=8;issue=2;spage=247;epage=256;aulast=Niudanhong injectionmetabolomicsperioperative percutaneous coronary interventionunstable angina pectoris |
| spellingShingle | Qian Niu Wen-Long Xing Yu-Tong Wang Yan Zhu Hong-Xu Liu Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics World Journal of Traditional Chinese Medicine danhong injection metabolomics perioperative percutaneous coronary intervention unstable angina pectoris |
| title | Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| title_full | Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| title_fullStr | Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| title_full_unstemmed | Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| title_short | Danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| title_sort | danhong injection improves elective percutaneous coronary intervention in ua patients with blood stasis syndrome revealed by perioperative metabolomics |
| topic | danhong injection metabolomics perioperative percutaneous coronary intervention unstable angina pectoris |
| url | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2022;volume=8;issue=2;spage=247;epage=256;aulast=Niu |
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