Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy”
We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantia...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.745734/full |
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| author | M. van Verseveld L. H. Koens L. H. Koens Tom J. de Koning Tom J. de Koning Tom J. de Koning R. L. E. Derikx J. A. van Waarde |
| author_facet | M. van Verseveld L. H. Koens L. H. Koens Tom J. de Koning Tom J. de Koning Tom J. de Koning R. L. E. Derikx J. A. van Waarde |
| author_sort | M. van Verseveld |
| collection | DOAJ |
| description | We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects. |
| first_indexed | 2024-12-17T22:10:29Z |
| format | Article |
| id | doaj.art-6abd57d2368b47febd7c69c0adaa9e24 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-17T22:10:29Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-6abd57d2368b47febd7c69c0adaa9e242022-12-21T21:30:45ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-10-011210.3389/fpsyt.2021.745734745734Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy”M. van Verseveld0L. H. Koens1L. H. Koens2Tom J. de Koning3Tom J. de Koning4Tom J. de Koning5R. L. E. Derikx6J. A. van Waarde7Department of Psychiatry, Rijnstate Hospital, Arnhem, NetherlandsDepartment of Neurology, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsExpertise Center Movement Disorders Groningen, University Medical Center Groningen, Groningen, NetherlandsExpertise Center Movement Disorders Groningen, University Medical Center Groningen, Groningen, NetherlandsDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsDepartment of Pediatrics, Clinical Sciences, Lund University, Lund, SwedenDepartment of Psychiatry, Rijnstate Hospital, Arnhem, NetherlandsDepartment of Psychiatry, Rijnstate Hospital, Arnhem, NetherlandsWe describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.745734/fullelectroconvulsive therapyinborn errors of metabolismNiemann-Pick type Ccatatoniaseizure threshold |
| spellingShingle | M. van Verseveld L. H. Koens L. H. Koens Tom J. de Koning Tom J. de Koning Tom J. de Koning R. L. E. Derikx J. A. van Waarde Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” Frontiers in Psychiatry electroconvulsive therapy inborn errors of metabolism Niemann-Pick type C catatonia seizure threshold |
| title | Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” |
| title_full | Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” |
| title_fullStr | Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” |
| title_full_unstemmed | Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” |
| title_short | Case Report: “Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy” |
| title_sort | case report niemann pick disease type c in a catatonic patient treated with electroconvulsive therapy |
| topic | electroconvulsive therapy inborn errors of metabolism Niemann-Pick type C catatonia seizure threshold |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.745734/full |
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