Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review
Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.789079/full |
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| author | Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi |
| author_facet | Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi |
| author_sort | Pierre Loap |
| collection | DOAJ |
| description | Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC. |
| first_indexed | 2024-12-14T14:20:47Z |
| format | Article |
| id | doaj.art-6abf9a0c59344ab7b3ad937177ddf0f3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T14:20:47Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6abf9a0c59344ab7b3ad937177ddf0f32022-12-21T22:58:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.789079789079Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative ReviewPierre Loap0Pierre Loap1Pierre Loap2Barbara Vischioni3Maria Bonora4Rossana Ingargiola5Sara Ronchi6Viviana Vitolo7Amelia Barcellini8Lucia Goanta9Ludovic De Marzi10Ludovic De Marzi11Ludovic De Marzi12Remi Dendale13Remi Dendale14Roberto Pacelli15Laura Locati16Laura Locati17Valentin Calugaru18Valentin Calugaru19Hamid Mammar20Hamid Mammar21Stefano Cavalieri22Stefano Cavalieri23Youlia Kirova24Youlia Kirova25Ester Orlandi26Radiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, Napoli, ItalyDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceInstitut Curie, PSL Research University, University Paris Saclay, INSERM LITO, Orsay, FranceDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”, Napoli, ItalyMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, ItalyDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceMedical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyDepartment of Oncology and Hemato-Oncology, University of Milan, Milan, ItalyDepartment of Radiation Oncology, Institut Curie, Paris, FranceProton Therapy Center, Institut Curie, Orsay, FranceRadiation Oncology Unit, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, ItalyAdenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.https://www.frontiersin.org/articles/10.3389/fonc.2021.789079/fulladenoid cyst carcinomahadrontherapycarbon ion radiotherapy (CIRT)tumor immunologyradioresistance |
| spellingShingle | Pierre Loap Pierre Loap Pierre Loap Barbara Vischioni Maria Bonora Rossana Ingargiola Sara Ronchi Viviana Vitolo Amelia Barcellini Lucia Goanta Ludovic De Marzi Ludovic De Marzi Ludovic De Marzi Remi Dendale Remi Dendale Roberto Pacelli Laura Locati Laura Locati Valentin Calugaru Valentin Calugaru Hamid Mammar Hamid Mammar Stefano Cavalieri Stefano Cavalieri Youlia Kirova Youlia Kirova Ester Orlandi Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review Frontiers in Oncology adenoid cyst carcinoma hadrontherapy carbon ion radiotherapy (CIRT) tumor immunology radioresistance |
| title | Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review |
| title_full | Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review |
| title_fullStr | Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review |
| title_full_unstemmed | Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review |
| title_short | Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review |
| title_sort | biological rationale and clinical evidence of carbon ion radiation therapy for adenoid cystic carcinoma a narrative review |
| topic | adenoid cyst carcinoma hadrontherapy carbon ion radiotherapy (CIRT) tumor immunology radioresistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.789079/full |
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