Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study
Background: The aim of this prospective study was to evaluate the efficacy and safety of Platelet Rich Plasma (PRP) injections in patients affected by knee osteoarthritis (KOA). An autologous blood product containing a high percentage of various growth factors (GFs), cytokines and modulating factors...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/9/2640 |
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| author | Lorenzo Moretti Giuseppe Maccagnano Michele Coviello Giuseppe D. Cassano Andrea Franchini Andrea Laneve Biagio Moretti |
| author_facet | Lorenzo Moretti Giuseppe Maccagnano Michele Coviello Giuseppe D. Cassano Andrea Franchini Andrea Laneve Biagio Moretti |
| author_sort | Lorenzo Moretti |
| collection | DOAJ |
| description | Background: The aim of this prospective study was to evaluate the efficacy and safety of Platelet Rich Plasma (PRP) injections in patients affected by knee osteoarthritis (KOA). An autologous blood product containing a high percentage of various growth factors (GFs), cytokines and modulating factors as PRP has shown promising results in achieving this goal. Methods: One hundred and fifty-three patients (72 males, mean age 59.06 ± 8.78, range 40–81 years old) from January 2018 to January 2020 received three consecutive PRP injections and completed the follow ups. Western Ontario and McMaster University Osteoarthritis index (WOMAC), Knee society score (KSS) and Visual Analogic Scale (VAS) were evaluated before PRP injection (T0), one month (T1), three months (T2) and six months (T3) after the treatment. All patients underwent baseline and at 6 months MRI and X-ray evaluation. Results: A statistically significant VAS, KSS and WOMAC reduction emerged in the comparison between evaluations (<i>p</i> < 0.05), MRI demonstrated non-statistically significant improvement in cartilage thickness for both tibial plate and femoral plate (<i>p</i> = 0.46 and <i>p</i> = 0.33 respectively), and no radiographic changes could be seen in any patients. Conclusions: PRP injection represents a valid conservative treatment to reduce pain, improve quality of life and functional scores even at midterm of 6 months follow-up. |
| first_indexed | 2024-03-10T04:00:29Z |
| format | Article |
| id | doaj.art-6ac2deb79b094e788795363308f3751c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:00:29Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6ac2deb79b094e788795363308f3751c2023-11-23T08:35:20ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-01119264010.3390/jcm11092640Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical StudyLorenzo Moretti0Giuseppe Maccagnano1Michele Coviello2Giuseppe D. Cassano3Andrea Franchini4Andrea Laneve5Biagio Moretti6Orthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, ItalyOrthopaedics Unit, Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia, 71122 Foggia, ItalyOrthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, ItalyOrthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, ItalyOrthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, ItalyOrthopaedics Unit, Department of Clinical and Experimental Medicine, Faculty of Medicine and Surgery, University of Foggia, Policlinico Riuniti di Foggia, 71122 Foggia, ItalyOrthopaedic & Trauma Unit, Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari Aldo Moro, AOU Consorziale Policlinico, 70124 Bari, ItalyBackground: The aim of this prospective study was to evaluate the efficacy and safety of Platelet Rich Plasma (PRP) injections in patients affected by knee osteoarthritis (KOA). An autologous blood product containing a high percentage of various growth factors (GFs), cytokines and modulating factors as PRP has shown promising results in achieving this goal. Methods: One hundred and fifty-three patients (72 males, mean age 59.06 ± 8.78, range 40–81 years old) from January 2018 to January 2020 received three consecutive PRP injections and completed the follow ups. Western Ontario and McMaster University Osteoarthritis index (WOMAC), Knee society score (KSS) and Visual Analogic Scale (VAS) were evaluated before PRP injection (T0), one month (T1), three months (T2) and six months (T3) after the treatment. All patients underwent baseline and at 6 months MRI and X-ray evaluation. Results: A statistically significant VAS, KSS and WOMAC reduction emerged in the comparison between evaluations (<i>p</i> < 0.05), MRI demonstrated non-statistically significant improvement in cartilage thickness for both tibial plate and femoral plate (<i>p</i> = 0.46 and <i>p</i> = 0.33 respectively), and no radiographic changes could be seen in any patients. Conclusions: PRP injection represents a valid conservative treatment to reduce pain, improve quality of life and functional scores even at midterm of 6 months follow-up.https://www.mdpi.com/2077-0383/11/9/2640knee osteoarthritis (KOA)cartilageplateled riched plasma (PRP)knee injectionbiologic therapy |
| spellingShingle | Lorenzo Moretti Giuseppe Maccagnano Michele Coviello Giuseppe D. Cassano Andrea Franchini Andrea Laneve Biagio Moretti Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study Journal of Clinical Medicine knee osteoarthritis (KOA) cartilage plateled riched plasma (PRP) knee injection biologic therapy |
| title | Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study |
| title_full | Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study |
| title_fullStr | Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study |
| title_full_unstemmed | Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study |
| title_short | Platelet Rich Plasma Injections for Knee Osteoarthritis Treatment: A Prospective Clinical Study |
| title_sort | platelet rich plasma injections for knee osteoarthritis treatment a prospective clinical study |
| topic | knee osteoarthritis (KOA) cartilage plateled riched plasma (PRP) knee injection biologic therapy |
| url | https://www.mdpi.com/2077-0383/11/9/2640 |
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