Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials
Purpose: To quantify the morphology of eyeballs with posterior staphyloma (PS) with Zernike decomposition and to explore the association between Zernike coefficients with existing PS classification.Methods: Fifty-three eyes with high myopia (HM, ≤-6.00D) and 30 with PS were included. PS was classifi...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126543/full |
| _version_ | 1811157816127258624 |
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| author | Hua Rong Lin Liu Yuling Liu Wanzeng Fu He Xu Danyang Yu Di Wu Bei Du Xuejun Zhang Bin Zhang Ruihua Wei |
| author_facet | Hua Rong Lin Liu Yuling Liu Wanzeng Fu He Xu Danyang Yu Di Wu Bei Du Xuejun Zhang Bin Zhang Ruihua Wei |
| author_sort | Hua Rong |
| collection | DOAJ |
| description | Purpose: To quantify the morphology of eyeballs with posterior staphyloma (PS) with Zernike decomposition and to explore the association between Zernike coefficients with existing PS classification.Methods: Fifty-three eyes with high myopia (HM, ≤-6.00D) and 30 with PS were included. PS was classified with traditional methods based on OCT findings. Eyeballs’ morphology was obtained with 3D MRI, from which the height map of the posterior surface was extracted. Zernike decomposition was performed to derive the coefficients of the 1st-27th items, which were compared between HM and PS eyes with the Mann-Whitney-U test. Receiver operating characteristics (ROC) analysis was used to test the effectiveness of using Zernike coefficients to discriminate PS from HM.Results: Compared to HM eyeballs, PS eyeballs had significantly increased vertical and horizontal tilt, oblique astigmatism, defocus, vertical and horizontal coma, and higher order aberrations (HOA) (all Ps < 0.05). HOA was the most effective in PS classification with an area under the ROC curve (AUROC) value of 0.977. Among the 30 PS, 19 were the wide macular type with large defocus and negative spherical aberration; 4 were the narrow macular type with positive spherical aberration; 3 were inferior PS with greater vertical tilt, and 4were peripapillary PS with larger horizontal tilt.Conclusion: PS eyes have significantly increased Zernike coefficients, and HOA is the most effective parameter to differentiate PS from HM. The geometrical meaning of the Zernike components showed great accordance with PS classification. |
| first_indexed | 2024-04-10T05:12:40Z |
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| id | doaj.art-6ac48080aefd4a5daa155930d05146bc |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T05:12:40Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-6ac48080aefd4a5daa155930d05146bc2023-03-09T06:17:01ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11265431126543Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomialsHua Rong0Lin Liu1Yuling Liu2Wanzeng Fu3He Xu4Danyang Yu5Di Wu6Bei Du7Xuejun Zhang8Bin Zhang9Ruihua Wei10Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaQcraft Inc., Beijing, ChinaDepartment of Radiology, Second Hospital of Tianjin Medical University, Tianjin, ChinaTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaDepartment of Radiology, Second Hospital of Tianjin Medical University, Tianjin, ChinaCollege of Optometry, Nova Southeastern University, Davie, FL, United StatesTianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaPurpose: To quantify the morphology of eyeballs with posterior staphyloma (PS) with Zernike decomposition and to explore the association between Zernike coefficients with existing PS classification.Methods: Fifty-three eyes with high myopia (HM, ≤-6.00D) and 30 with PS were included. PS was classified with traditional methods based on OCT findings. Eyeballs’ morphology was obtained with 3D MRI, from which the height map of the posterior surface was extracted. Zernike decomposition was performed to derive the coefficients of the 1st-27th items, which were compared between HM and PS eyes with the Mann-Whitney-U test. Receiver operating characteristics (ROC) analysis was used to test the effectiveness of using Zernike coefficients to discriminate PS from HM.Results: Compared to HM eyeballs, PS eyeballs had significantly increased vertical and horizontal tilt, oblique astigmatism, defocus, vertical and horizontal coma, and higher order aberrations (HOA) (all Ps < 0.05). HOA was the most effective in PS classification with an area under the ROC curve (AUROC) value of 0.977. Among the 30 PS, 19 were the wide macular type with large defocus and negative spherical aberration; 4 were the narrow macular type with positive spherical aberration; 3 were inferior PS with greater vertical tilt, and 4were peripapillary PS with larger horizontal tilt.Conclusion: PS eyes have significantly increased Zernike coefficients, and HOA is the most effective parameter to differentiate PS from HM. The geometrical meaning of the Zernike components showed great accordance with PS classification.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126543/fullposterior staphyloma3D MRIhigh myopiaZernike polynomialseyeball morphology |
| spellingShingle | Hua Rong Lin Liu Yuling Liu Wanzeng Fu He Xu Danyang Yu Di Wu Bei Du Xuejun Zhang Bin Zhang Ruihua Wei Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials Frontiers in Bioengineering and Biotechnology posterior staphyloma 3D MRI high myopia Zernike polynomials eyeball morphology |
| title | Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials |
| title_full | Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials |
| title_fullStr | Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials |
| title_full_unstemmed | Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials |
| title_short | Quantifying the morphology of eyeballs with posterior staphyloma with Zernike polynomials |
| title_sort | quantifying the morphology of eyeballs with posterior staphyloma with zernike polynomials |
| topic | posterior staphyloma 3D MRI high myopia Zernike polynomials eyeball morphology |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126543/full |
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