Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect
The “Warburg effect” describes the reprogramming of glucose metabolism away from oxidative phosphorylation toward aerobic glycolysis, and it is one of the hallmarks of cancer cells. Several factors can be involved in this process, but in this review, the roles of non-coding RNAs (ncRNAs) are highlig...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770520301546 |
| _version_ | 1819061099427790848 |
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| author | Hamed Mirzaei Michael R. Hamblin |
| author_facet | Hamed Mirzaei Michael R. Hamblin |
| author_sort | Hamed Mirzaei |
| collection | DOAJ |
| description | The “Warburg effect” describes the reprogramming of glucose metabolism away from oxidative phosphorylation toward aerobic glycolysis, and it is one of the hallmarks of cancer cells. Several factors can be involved in this process, but in this review, the roles of non-coding RNAs (ncRNAs) are highlighted in several types of human cancer. ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, can all affect metabolic enzymes and transcription factors to promote glycolysis and modulate glucose metabolism to enhance the progression of tumors. In particular, the 5′-AMP-activated protein kinase (AMPK) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathways are associated with alterations in ncRNAs. A better understanding of the roles of ncRNAs in the Warburg effect could ultimately lead to new therapeutic approaches for suppressing cancer. |
| first_indexed | 2024-12-21T14:37:30Z |
| format | Article |
| id | doaj.art-6ac6e700983d4035813b98afacc5c1cd |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-12-21T14:37:30Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-6ac6e700983d4035813b98afacc5c1cd2022-12-21T19:00:17ZengElsevierMolecular Therapy: Oncolytics2372-77052020-12-0119218239Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg EffectHamed Mirzaei0Michael R. Hamblin1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran; Corresponding author: Hamed Mirzaei, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, Johannesburg 2028, South AfricaThe “Warburg effect” describes the reprogramming of glucose metabolism away from oxidative phosphorylation toward aerobic glycolysis, and it is one of the hallmarks of cancer cells. Several factors can be involved in this process, but in this review, the roles of non-coding RNAs (ncRNAs) are highlighted in several types of human cancer. ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs, can all affect metabolic enzymes and transcription factors to promote glycolysis and modulate glucose metabolism to enhance the progression of tumors. In particular, the 5′-AMP-activated protein kinase (AMPK) and the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathways are associated with alterations in ncRNAs. A better understanding of the roles of ncRNAs in the Warburg effect could ultimately lead to new therapeutic approaches for suppressing cancer.http://www.sciencedirect.com/science/article/pii/S2372770520301546glycolysisnon-coding RNAscancerWarburg effect |
| spellingShingle | Hamed Mirzaei Michael R. Hamblin Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect Molecular Therapy: Oncolytics glycolysis non-coding RNAs cancer Warburg effect |
| title | Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect |
| title_full | Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect |
| title_fullStr | Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect |
| title_full_unstemmed | Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect |
| title_short | Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect |
| title_sort | regulation of glycolysis by non coding rnas in cancer switching on the warburg effect |
| topic | glycolysis non-coding RNAs cancer Warburg effect |
| url | http://www.sciencedirect.com/science/article/pii/S2372770520301546 |
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