Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/12/10/2261 |
| _version_ | 1797552088516919296 |
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| author | Sheila Maiz-Fernández Leyre Pérez-Álvarez Leire Ruiz-Rubio Jose Luis Vilas-Vilela Senentxu Lanceros-Mendez |
| author_facet | Sheila Maiz-Fernández Leyre Pérez-Álvarez Leire Ruiz-Rubio Jose Luis Vilas-Vilela Senentxu Lanceros-Mendez |
| author_sort | Sheila Maiz-Fernández |
| collection | DOAJ |
| description | In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration. |
| first_indexed | 2024-03-10T15:55:00Z |
| format | Article |
| id | doaj.art-6ac6f166112649c39c4b6e5d3978c92d |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T15:55:00Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-6ac6f166112649c39c4b6e5d3978c92d2023-11-20T15:46:31ZengMDPI AGPolymers2073-43602020-10-011210226110.3390/polym12102261Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering ApplicationsSheila Maiz-Fernández0Leyre Pérez-Álvarez1Leire Ruiz-Rubio2Jose Luis Vilas-Vilela3Senentxu Lanceros-Mendez4BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, SpainBCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, SpainBCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, SpainBCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, SpainBCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, SpainIn situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.https://www.mdpi.com/2073-4360/12/10/2261polysaccharideself-healingin situ hydrogelsdynamic bondsinjectabilitytissue engineering |
| spellingShingle | Sheila Maiz-Fernández Leyre Pérez-Álvarez Leire Ruiz-Rubio Jose Luis Vilas-Vilela Senentxu Lanceros-Mendez Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications Polymers polysaccharide self-healing in situ hydrogels dynamic bonds injectability tissue engineering |
| title | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications |
| title_full | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications |
| title_fullStr | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications |
| title_full_unstemmed | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications |
| title_short | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications |
| title_sort | polysaccharide based in situ self healing hydrogels for tissue engineering applications |
| topic | polysaccharide self-healing in situ hydrogels dynamic bonds injectability tissue engineering |
| url | https://www.mdpi.com/2073-4360/12/10/2261 |
| work_keys_str_mv | AT sheilamaizfernandez polysaccharidebasedinsituselfhealinghydrogelsfortissueengineeringapplications AT leyreperezalvarez polysaccharidebasedinsituselfhealinghydrogelsfortissueengineeringapplications AT leireruizrubio polysaccharidebasedinsituselfhealinghydrogelsfortissueengineeringapplications AT joseluisvilasvilela polysaccharidebasedinsituselfhealinghydrogelsfortissueengineeringapplications AT senentxulancerosmendez polysaccharidebasedinsituselfhealinghydrogelsfortissueengineeringapplications |