Ultrasonic actuation of a fine-needle improves biopsy yield
Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical nee...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-87303-x |
| _version_ | 1818401628377579520 |
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| author | Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen |
| author_facet | Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen |
| author_sort | Emanuele Perra |
| collection | DOAJ |
| description | Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures. |
| first_indexed | 2024-12-14T07:55:29Z |
| format | Article |
| id | doaj.art-6ac85d15a7c24e85b23285311eb942ee |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:55:29Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6ac85d15a7c24e85b23285311eb942ee2022-12-21T23:10:32ZengNature PortfolioScientific Reports2045-23222021-04-0111111510.1038/s41598-021-87303-xUltrasonic actuation of a fine-needle improves biopsy yieldEmanuele Perra0Eetu Lampsijärvi1Gonçalo Barreto2Muhammad Arif3Tuomas Puranen4Edward Hæggström5Kenneth P. H. Pritzker6Heikki J. Nieminen7Medical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto UniversityElectronics Research Laboratory, Department of Physics, University of HelsinkiTranslational Immunology Research Program, University of HelsinkiMedical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto UniversityElectronics Research Laboratory, Department of Physics, University of HelsinkiElectronics Research Laboratory, Department of Physics, University of HelsinkiDepartment of Laboratory Medicine and Pathobiology, University of TorontoMedical Ultrasonics Laboratory (MEDUSA), Department of Neuroscience and Biomedical Engineering, Aalto UniversityAbstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.https://doi.org/10.1038/s41598-021-87303-x |
| spellingShingle | Emanuele Perra Eetu Lampsijärvi Gonçalo Barreto Muhammad Arif Tuomas Puranen Edward Hæggström Kenneth P. H. Pritzker Heikki J. Nieminen Ultrasonic actuation of a fine-needle improves biopsy yield Scientific Reports |
| title | Ultrasonic actuation of a fine-needle improves biopsy yield |
| title_full | Ultrasonic actuation of a fine-needle improves biopsy yield |
| title_fullStr | Ultrasonic actuation of a fine-needle improves biopsy yield |
| title_full_unstemmed | Ultrasonic actuation of a fine-needle improves biopsy yield |
| title_short | Ultrasonic actuation of a fine-needle improves biopsy yield |
| title_sort | ultrasonic actuation of a fine needle improves biopsy yield |
| url | https://doi.org/10.1038/s41598-021-87303-x |
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