Systems redox biology in health and disease
Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become integrated across and between different levels of org...
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| Format: | Article |
| Language: | English |
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IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
2022-03-01
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| Series: | EXCLI Journal : Experimental and Clinical Sciences |
| Subjects: | |
| Online Access: | https://www.excli.de/index.php/excli/article/view/4793 |
| _version_ | 1797843511713726464 |
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| author | Martin Feelisch Miriam M. Cortese-Krott Jérôme Santolini Stephen A. Wootton Alan A. Jackson |
| author_facet | Martin Feelisch Miriam M. Cortese-Krott Jérôme Santolini Stephen A. Wootton Alan A. Jackson |
| author_sort | Martin Feelisch |
| collection | DOAJ |
| description | Living organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become integrated across and between different levels of organization within an organism can provide a different perspective on the nature and inter-relationship of complex systems in health and disease. We here compare two concepts which have been very influential in stress research: Selye’s ‘General Adaptation Syndrome’ and Sies’s ‘Oxidative Stress’ paradigm. We show that both can be embraced within a more general framework of ‘change and response’. The ‘Reactive Species Interactome’ allows each of these to be considered as distinct but complementary aspects of the same system, representative of roles at different levels of organization within a functional hierarchy. The versatile chemistry of sulfur - exemplified by hydrogen sulfide, glutathione and proteinous cysteine thiols - enriched by its interactions with reactive oxygen, nitrogen and sulfur species, would seem to sit at the heart of the ‘Redox Code’ and underpin the ability of complex organisms to cope with stress. |
| first_indexed | 2024-04-09T17:06:26Z |
| format | Article |
| id | doaj.art-6ac8a5075a244c80824f2f5a73631937 |
| institution | Directory Open Access Journal |
| issn | 1611-2156 |
| language | English |
| last_indexed | 2024-04-09T17:06:26Z |
| publishDate | 2022-03-01 |
| publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| record_format | Article |
| series | EXCLI Journal : Experimental and Clinical Sciences |
| spelling | doaj.art-6ac8a5075a244c80824f2f5a736319372023-04-20T13:21:01ZengIfADo - Leibniz Research Centre for Working Environment and Human Factors, DortmundEXCLI Journal : Experimental and Clinical Sciences1611-21562022-03-012162364610.17179/excli2022-47934232Systems redox biology in health and diseaseMartin Feelisch0https://orcid.org/0000-0003-2320-1158Miriam M. Cortese-Krott1https://orcid.org/0000-0002-0593-1192Jérôme Santolini2https://orcid.org/0000-0001-8919-112XStephen A. Wootton3https://orcid.org/0000-0002-9495-9719Alan A. Jackson4https://orcid.org/0000-0001-8075-3667Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton and NIHR Biomedical Research Center, University Hospital Southampton, NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD, UK. Phone: +44-2381 20 6891; E-mail: M.Feelisch@soton.ac.ukMyocardial Infarction Research Laboratory, Department of Cardiology, Pulmonology and Angiology, Medical Faculty, Heinrich Heine University of Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf, GermanyInstitute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris-Sud, Université Paris-Saclay, F-91198, Gif-sur-Yvette Cedex, FranceInstitute of Human Nutrition, University of Southampton and University Hospital Southampton, Tremona Road, Southampton, SO16 6YD, UKInstitute of Human Nutrition, University of Southampton and University Hospital Southampton, Tremona Road, Southampton, SO16 6YD, UKLiving organisms need to be able to cope with environmental challenges and other stressors and mount adequate responses that are as varied as the spectrum of those challenges. Understanding how the multi-layered biological stress responses become integrated across and between different levels of organization within an organism can provide a different perspective on the nature and inter-relationship of complex systems in health and disease. We here compare two concepts which have been very influential in stress research: Selye’s ‘General Adaptation Syndrome’ and Sies’s ‘Oxidative Stress’ paradigm. We show that both can be embraced within a more general framework of ‘change and response’. The ‘Reactive Species Interactome’ allows each of these to be considered as distinct but complementary aspects of the same system, representative of roles at different levels of organization within a functional hierarchy. The versatile chemistry of sulfur - exemplified by hydrogen sulfide, glutathione and proteinous cysteine thiols - enriched by its interactions with reactive oxygen, nitrogen and sulfur species, would seem to sit at the heart of the ‘Redox Code’ and underpin the ability of complex organisms to cope with stress.https://www.excli.de/index.php/excli/article/view/4793integrated physiologysystems medicineoxidative stresshydrogen sulfideredox signalingnutrition |
| spellingShingle | Martin Feelisch Miriam M. Cortese-Krott Jérôme Santolini Stephen A. Wootton Alan A. Jackson Systems redox biology in health and disease EXCLI Journal : Experimental and Clinical Sciences integrated physiology systems medicine oxidative stress hydrogen sulfide redox signaling nutrition |
| title | Systems redox biology in health and disease |
| title_full | Systems redox biology in health and disease |
| title_fullStr | Systems redox biology in health and disease |
| title_full_unstemmed | Systems redox biology in health and disease |
| title_short | Systems redox biology in health and disease |
| title_sort | systems redox biology in health and disease |
| topic | integrated physiology systems medicine oxidative stress hydrogen sulfide redox signaling nutrition |
| url | https://www.excli.de/index.php/excli/article/view/4793 |
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