Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats
Background and Aim: It has been indicated that aluminum phosphide (ALP) and paraquat (PQ) poisoning generate oxidative stress through the production of free radicals. The aim of the present study was to examine the effect of hydro alcoholic extract of Persian shallot and N-acetyl cysteine (NAC) agai...
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| Format: | Article |
| Language: | English |
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Lorestan University of Medical Sciences
2021-10-01
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| Series: | Herbal Medicines Journal |
| Online Access: | http://hmj.lums.ac.ir/index.php/hmj/article/view/783 |
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| author | Hassan Ghasemi Seyed Mostafa Hosseini Zijoud Nejat Khiripour Omid Heidari Shayesteh Amir Nili-Ahmadabadi Akram Ranjbar* |
| author_facet | Hassan Ghasemi Seyed Mostafa Hosseini Zijoud Nejat Khiripour Omid Heidari Shayesteh Amir Nili-Ahmadabadi Akram Ranjbar* |
| author_sort | Hassan Ghasemi |
| collection | DOAJ |
| description | Background and Aim: It has been indicated that aluminum phosphide (ALP) and paraquat (PQ) poisoning generate oxidative stress through the production of free radicals. The aim of the present study was to examine the effect of hydro alcoholic extract of Persian shallot and N-acetyl cysteine (NAC) against induced oxidative stress by PQ and ALP.
Materials and Methods: Adult male Wister rats were divided into ten groups of 7. Animals received ALP and PQ alone and also in combination with NAC and the hydro alcoholic extract of Persian shallot. After twenty-four hours of treatment, the animals were scarified and their blood as well as liver samples were collected. Then, alanine aminotransferase (ALT), aspartate aminotransferase (AST), catalase (CAT) activity, as well as total antioxidant capacity (TAC) and lipid peroxidation (LPO) were measured.
Results: The PQ and ALP significantly increased ALT and AST leakage compared to the control group (P<0.05). The TAC of serum and liver remarkably increased in the groups treated with NAC and hydro alcoholic extracts of Persian shallot in comparison with the control group (P < 0.05).
Conclusion: As a natural antioxidant, the hydro alcoholic extract of Persian shallot can counteract with oxidative stress induced by ALP and PQ to ameliorate liver function.
Keywords: Persian Shallot, Oxidative stress, N-acetyl cysteine, Aluminum Phosphide, Paraquat |
| first_indexed | 2024-04-11T19:07:20Z |
| format | Article |
| id | doaj.art-6ac9b633030745b8803d3c282a8992cc |
| institution | Directory Open Access Journal |
| issn | 2538-2144 |
| language | English |
| last_indexed | 2024-04-11T19:07:20Z |
| publishDate | 2021-10-01 |
| publisher | Lorestan University of Medical Sciences |
| record_format | Article |
| series | Herbal Medicines Journal |
| spelling | doaj.art-6ac9b633030745b8803d3c282a8992cc2022-12-22T04:07:42ZengLorestan University of Medical SciencesHerbal Medicines Journal2538-21442021-10-0153Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in RatsHassan Ghasemi0Seyed Mostafa Hosseini Zijoud1Nejat Khiripour2Omid Heidari Shayesteh3Amir Nili-Ahmadabadi4Akram Ranjbar*5Abadan School of Medical Sciences, Abadan, IranDepartment of Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IranMedical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranMedical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranMedical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, IranBackground and Aim: It has been indicated that aluminum phosphide (ALP) and paraquat (PQ) poisoning generate oxidative stress through the production of free radicals. The aim of the present study was to examine the effect of hydro alcoholic extract of Persian shallot and N-acetyl cysteine (NAC) against induced oxidative stress by PQ and ALP. Materials and Methods: Adult male Wister rats were divided into ten groups of 7. Animals received ALP and PQ alone and also in combination with NAC and the hydro alcoholic extract of Persian shallot. After twenty-four hours of treatment, the animals were scarified and their blood as well as liver samples were collected. Then, alanine aminotransferase (ALT), aspartate aminotransferase (AST), catalase (CAT) activity, as well as total antioxidant capacity (TAC) and lipid peroxidation (LPO) were measured. Results: The PQ and ALP significantly increased ALT and AST leakage compared to the control group (P<0.05). The TAC of serum and liver remarkably increased in the groups treated with NAC and hydro alcoholic extracts of Persian shallot in comparison with the control group (P < 0.05). Conclusion: As a natural antioxidant, the hydro alcoholic extract of Persian shallot can counteract with oxidative stress induced by ALP and PQ to ameliorate liver function. Keywords: Persian Shallot, Oxidative stress, N-acetyl cysteine, Aluminum Phosphide, Paraquathttp://hmj.lums.ac.ir/index.php/hmj/article/view/783 |
| spellingShingle | Hassan Ghasemi Seyed Mostafa Hosseini Zijoud Nejat Khiripour Omid Heidari Shayesteh Amir Nili-Ahmadabadi Akram Ranjbar* Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats Herbal Medicines Journal |
| title | Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats |
| title_full | Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats |
| title_fullStr | Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats |
| title_full_unstemmed | Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats |
| title_short | Effects of Allium Hirtifolium Hydroalcoholic Extract and N-acetylcysteine on the Oxidative Toxic Stress Biomarkers in Aluminum Phosphide and Paraquat Toxicity in Rats |
| title_sort | effects of allium hirtifolium hydroalcoholic extract and n acetylcysteine on the oxidative toxic stress biomarkers in aluminum phosphide and paraquat toxicity in rats |
| url | http://hmj.lums.ac.ir/index.php/hmj/article/view/783 |
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