MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex
Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11692-x |
| _version_ | 1818684814203551744 |
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| author | Benjamin Gottschalk Christiane Klec Gerd Leitinger Eva Bernhart René Rost Helmut Bischof Corina T. Madreiter-Sokolowski Snježana Radulović Emrah Eroglu Wolfgang Sattler Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier |
| author_facet | Benjamin Gottschalk Christiane Klec Gerd Leitinger Eva Bernhart René Rost Helmut Bischof Corina T. Madreiter-Sokolowski Snježana Radulović Emrah Eroglu Wolfgang Sattler Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier |
| author_sort | Benjamin Gottschalk |
| collection | DOAJ |
| description | Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure. |
| first_indexed | 2024-12-17T10:56:36Z |
| format | Article |
| id | doaj.art-6ac9bbcf957c4a56ad8f56403898e532 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:56:36Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6ac9bbcf957c4a56ad8f56403898e5322022-12-21T21:51:47ZengNature PortfolioNature Communications2041-17232019-08-0110111710.1038/s41467-019-11692-xMICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complexBenjamin Gottschalk0Christiane Klec1Gerd Leitinger2Eva Bernhart3René Rost4Helmut Bischof5Corina T. Madreiter-Sokolowski6Snježana Radulović7Emrah Eroglu8Wolfgang Sattler9Markus Waldeck-Weiermair10Roland Malli11Wolfgang F. Graier12Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Cell Biology, Histology and Embryology, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of GrazProper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitochondrial membrane structure.https://doi.org/10.1038/s41467-019-11692-x |
| spellingShingle | Benjamin Gottschalk Christiane Klec Gerd Leitinger Eva Bernhart René Rost Helmut Bischof Corina T. Madreiter-Sokolowski Snježana Radulović Emrah Eroglu Wolfgang Sattler Markus Waldeck-Weiermair Roland Malli Wolfgang F. Graier MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex Nature Communications |
| title | MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex |
| title_full | MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex |
| title_fullStr | MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex |
| title_full_unstemmed | MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex |
| title_short | MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex |
| title_sort | micu1 controls cristae junction and spatially anchors mitochondrial ca2 uniporter complex |
| url | https://doi.org/10.1038/s41467-019-11692-x |
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