Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities
Head and neck squamous cell carcinoma (HNSCC) belongs to the most frequent cancer subtypes in the world. Mutations due to genetic and chromosomal instability, syndromes such as Fanconi anemia and the Bloom syndrome, environmental risk factors such as tobacco smoking, alcohol and human papillomavirus...
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| Format: | Article |
| Language: | English |
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Balkan Stomatological Society
2021-07-01
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| Series: | Balkan Journal of Dental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/bjdm-2021-0012 |
| _version_ | 1818200083365101568 |
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| author | Zisis Vasileios Venou Maria Poulopoulos Athanasios Andreadis Dimitrios |
| author_facet | Zisis Vasileios Venou Maria Poulopoulos Athanasios Andreadis Dimitrios |
| author_sort | Zisis Vasileios |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) belongs to the most frequent cancer subtypes in the world. Mutations due to genetic and chromosomal instability, syndromes such as Fanconi anemia and the Bloom syndrome, environmental risk factors such as tobacco smoking, alcohol and human papillomavirus infection (HPV) subtypes 16,18,31,33,35,52,58 are implicated in its pathogenesis. The HNSCC belongs to the solid tumors of epithelial origin and consists of stromal, inflammatory, cancer cells and most importantly a fraction of them, the cancer stem cells (CSCs). The identification of the CSCs through their biomarkers such as CD44, CD10, CD166, CD133, CD271, ALDH, Oct4, Nanog, Sox2 and Bmi1, the maintenance of their subpopulation through epithelial to mesenchymal transition, the role of HPV infection regarding their prognosis and of their microenvironment regarding their resistance to therapy, all constitute key elements that must be taken thoroughly into consideration in order to develop an effective targeted therapy. There are already therapies in place targeting specific related biomarkers, important biochemical pathways and growth factors. The aim of this literature review is to illustrate the treatment modalities available against the cancer stem cells of head and neck squamous cell carcinoma. |
| first_indexed | 2024-12-12T02:32:01Z |
| format | Article |
| id | doaj.art-6ac9edcdfafc4aeb945a056c04fae782 |
| institution | Directory Open Access Journal |
| issn | 2335-0245 |
| language | English |
| last_indexed | 2024-12-12T02:32:01Z |
| publishDate | 2021-07-01 |
| publisher | Balkan Stomatological Society |
| record_format | Article |
| series | Balkan Journal of Dental Medicine |
| spelling | doaj.art-6ac9edcdfafc4aeb945a056c04fae7822022-12-22T00:41:23ZengBalkan Stomatological SocietyBalkan Journal of Dental Medicine2335-02452021-07-01252737910.2478/bjdm-2021-0012Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment ModalitiesZisis Vasileios0Venou Maria1Poulopoulos Athanasios2Andreadis Dimitrios3Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, GreeceDepartment of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, GreeceDepartment of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, GreeceDepartment of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, GreeceHead and neck squamous cell carcinoma (HNSCC) belongs to the most frequent cancer subtypes in the world. Mutations due to genetic and chromosomal instability, syndromes such as Fanconi anemia and the Bloom syndrome, environmental risk factors such as tobacco smoking, alcohol and human papillomavirus infection (HPV) subtypes 16,18,31,33,35,52,58 are implicated in its pathogenesis. The HNSCC belongs to the solid tumors of epithelial origin and consists of stromal, inflammatory, cancer cells and most importantly a fraction of them, the cancer stem cells (CSCs). The identification of the CSCs through their biomarkers such as CD44, CD10, CD166, CD133, CD271, ALDH, Oct4, Nanog, Sox2 and Bmi1, the maintenance of their subpopulation through epithelial to mesenchymal transition, the role of HPV infection regarding their prognosis and of their microenvironment regarding their resistance to therapy, all constitute key elements that must be taken thoroughly into consideration in order to develop an effective targeted therapy. There are already therapies in place targeting specific related biomarkers, important biochemical pathways and growth factors. The aim of this literature review is to illustrate the treatment modalities available against the cancer stem cells of head and neck squamous cell carcinoma.https://doi.org/10.2478/bjdm-2021-0012cancer stem cellsoral canceroral cancer stem cellshead and neck cancerhpv and cancercancer stem cells treatment |
| spellingShingle | Zisis Vasileios Venou Maria Poulopoulos Athanasios Andreadis Dimitrios Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities Balkan Journal of Dental Medicine cancer stem cells oral cancer oral cancer stem cells head and neck cancer hpv and cancer cancer stem cells treatment |
| title | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities |
| title_full | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities |
| title_fullStr | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities |
| title_full_unstemmed | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities |
| title_short | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma-Treatment Modalities |
| title_sort | cancer stem cells in head and neck squamous cell carcinoma treatment modalities |
| topic | cancer stem cells oral cancer oral cancer stem cells head and neck cancer hpv and cancer cancer stem cells treatment |
| url | https://doi.org/10.2478/bjdm-2021-0012 |
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