Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis
(1) Background: Reversible cerebral vasoconstriction syndrome (RCVS) encompasses a clinical and radiological diagnosis characterized by recurrent thunderclap headache, with or without focal deficits due to multifocal arterial vasoconstriction and dilation. RCVS can be correlated to pregnancy and exp...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/14/2/40 |
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| author | Kimberly Pacheco Juan Fernando Ortiz Jashank Parwani Claudio Cruz Mario Yépez Maja Buj Mahika Khurana Diego Ojeda Alisson Iturburu Alex S. Aguirre Ray Yuen Shae Datta |
| author_facet | Kimberly Pacheco Juan Fernando Ortiz Jashank Parwani Claudio Cruz Mario Yépez Maja Buj Mahika Khurana Diego Ojeda Alisson Iturburu Alex S. Aguirre Ray Yuen Shae Datta |
| author_sort | Kimberly Pacheco |
| collection | DOAJ |
| description | (1) Background: Reversible cerebral vasoconstriction syndrome (RCVS) encompasses a clinical and radiological diagnosis characterized by recurrent thunderclap headache, with or without focal deficits due to multifocal arterial vasoconstriction and dilation. RCVS can be correlated to pregnancy and exposure to certain drugs. Currently, the data on prevalence of RCVS in the postpartum period is lacking. We aim to investigate the prevalence of RCVS in the postpartum period and the rate of hemorrhagic complications of RCVS among the same group of patients; (2) Methods: We conducted the metanalysis by using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-Analyses and Systematic Reviews of Observational Studies in Epidemiology (MOOSE) protocol. To analyze the Bias, we used the Ottawa Newcastle scale tool. We included only full-text observational studies conducted on humans and written in English. We excluded Literature Reviews, Systematic Reviews, and Metanalysis. Additionally, we excluded articles that did not document the prevalence of RCVS in the postpartum period (3). Results: According to our analysis, the Prevalence of RCVS in the postpartum period was 129/1083 (11.9%). Of these, 51/100 (52.7%) patients had hemorrhagic RCVS vs. 49/101 (49.5%) with non-hemorrhagic RCVS. The rates of Intracerebral Hemorrhage (ICH) and Subarachnoid Hemorrhage (SAH) were (51.6% and 10.7%, respectively. ICH seems to be more common than.; (4) Conclusions: Among patients with RCVS, the prevalence in PP patients is relativity high. Pregnant women with RCVS have a higher recurrence of hemorrhagic vs. non-hemorrhagic RCVS. Regarding the type of Hemorrhagic RCVS, ICH is more common than SAH among patients in the postpartum period. Female Sex, history of migraine, and older age group (above 45) seem to be risk factors for H-RCVS. Furthermore, recurrence of RCVS is associated with a higher age group (above 45). Recurrence of RCVS is more commonly idiopathic than being triggered by vasoactive drugs in the postpartum period. |
| first_indexed | 2024-03-09T22:51:20Z |
| format | Article |
| id | doaj.art-6acacd7850914a4fb9cfd224c8732906 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-09T22:51:20Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-6acacd7850914a4fb9cfd224c87329062023-11-23T18:18:47ZengMDPI AGNeurology International2035-83772022-05-0114248849610.3390/neurolint14020040Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-AnalysisKimberly Pacheco0Juan Fernando Ortiz1Jashank Parwani2Claudio Cruz3Mario Yépez4Maja Buj5Mahika Khurana6Diego Ojeda7Alisson Iturburu8Alex S. Aguirre9Ray Yuen10Shae Datta11School of Medicine, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito 170901, EcuadorDepartment of Neurology, California Institute of Behavioral Neuroscience & Psychology, Fairfield, CA 94534, USANeurology, Lokmanya Tilak Municipal Medical College, Mumbai 400022, IndiaSchool of Medicine, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito 170901, EcuadorSchool of Medicine, Colegio de Ciencias de la Salud, Universidad Católica Santiago de Guayaquil, Guayaquil 090615, EcuadorEast Side Medical Practice, New York, NY 10075, USADepartment of Public Health, University of California, Berkeley, CA 94720, USASchool of Medicine, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito 170901, EcuadorSchool of Medicine, Colegio de Ciencias de la Salud, Universidad de Guayaquil, Guayaquil 090510, EcuadorSchool of Medicine, Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito 170901, EcuadorNeurology Department, Larkin Community Hospital, Miami, FL 33143, USANeurology Department, NYU Langone Health, New York, NY 10017, USA(1) Background: Reversible cerebral vasoconstriction syndrome (RCVS) encompasses a clinical and radiological diagnosis characterized by recurrent thunderclap headache, with or without focal deficits due to multifocal arterial vasoconstriction and dilation. RCVS can be correlated to pregnancy and exposure to certain drugs. Currently, the data on prevalence of RCVS in the postpartum period is lacking. We aim to investigate the prevalence of RCVS in the postpartum period and the rate of hemorrhagic complications of RCVS among the same group of patients; (2) Methods: We conducted the metanalysis by using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-Analyses and Systematic Reviews of Observational Studies in Epidemiology (MOOSE) protocol. To analyze the Bias, we used the Ottawa Newcastle scale tool. We included only full-text observational studies conducted on humans and written in English. We excluded Literature Reviews, Systematic Reviews, and Metanalysis. Additionally, we excluded articles that did not document the prevalence of RCVS in the postpartum period (3). Results: According to our analysis, the Prevalence of RCVS in the postpartum period was 129/1083 (11.9%). Of these, 51/100 (52.7%) patients had hemorrhagic RCVS vs. 49/101 (49.5%) with non-hemorrhagic RCVS. The rates of Intracerebral Hemorrhage (ICH) and Subarachnoid Hemorrhage (SAH) were (51.6% and 10.7%, respectively. ICH seems to be more common than.; (4) Conclusions: Among patients with RCVS, the prevalence in PP patients is relativity high. Pregnant women with RCVS have a higher recurrence of hemorrhagic vs. non-hemorrhagic RCVS. Regarding the type of Hemorrhagic RCVS, ICH is more common than SAH among patients in the postpartum period. Female Sex, history of migraine, and older age group (above 45) seem to be risk factors for H-RCVS. Furthermore, recurrence of RCVS is associated with a higher age group (above 45). Recurrence of RCVS is more commonly idiopathic than being triggered by vasoactive drugs in the postpartum period.https://www.mdpi.com/2035-8377/14/2/40RCVSpostpartumhemorrhagic |
| spellingShingle | Kimberly Pacheco Juan Fernando Ortiz Jashank Parwani Claudio Cruz Mario Yépez Maja Buj Mahika Khurana Diego Ojeda Alisson Iturburu Alex S. Aguirre Ray Yuen Shae Datta Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis Neurology International RCVS postpartum hemorrhagic |
| title | Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis |
| title_full | Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis |
| title_fullStr | Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis |
| title_short | Reversible Cerebral Vasoconstriction Syndrome in the Postpartum Period: A Systematic Review and Meta-Analysis |
| title_sort | reversible cerebral vasoconstriction syndrome in the postpartum period a systematic review and meta analysis |
| topic | RCVS postpartum hemorrhagic |
| url | https://www.mdpi.com/2035-8377/14/2/40 |
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