Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor
Abstract Background Therapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-019-1348-x |
| _version_ | 1798034649041076224 |
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| author | Masafumi Maseda Hiroshi Uei Masahiro Nakahashi Hirokatsu Sawada Yasuaki Tokuhashi |
| author_facet | Masafumi Maseda Hiroshi Uei Masahiro Nakahashi Hirokatsu Sawada Yasuaki Tokuhashi |
| author_sort | Masafumi Maseda |
| collection | DOAJ |
| description | Abstract Background Therapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-preventing effect of treatment. Thus, we investigated the neurological outcome after treatment of patients with spinal cord compression in a state of impending paralysis. Methods A retrospective cohort study. The subjects were 88 patients with epidural spinal cord compression (ESCC) scale 1b or severer compression with American Spinal Injury Association (ASIA) E spinal metastasis. The neurological outcome after the therapeutic intervention was investigated at regular intervals until death. The therapeutic intervention was posterior decompression and stabilization in 18 patients, stabilization without posterior decompression in 15, and radiotherapy in 55 patients (3 groups). Results The ASIA aggravation group was comprised of 15 patients, and the severity of paralysis was ASIA A in 3, B in 3, C in 6, and D in 3. Paralysis appeared in 16.7% in the posterior decompression and stabilization group, 13.3% in the posterior stabilization without decompression group, and 18.8% in the radiotherapy group. In the transverse view, the incidence was high in cases with advancement to the intervertebral foramen and circumferential-type advancement, and paralysis developed in more than 20% of ESCC 1c or severer cases. Factors influencing neurological aggravation were investigated, but there was no significant factor. Conclusion In ESCC 1b or severer cases with ASIA E spinal metastasis, paralysis aggravated after therapeutic intervention in 16.7% in the posterior decompression and stabilization group, 13.3% in the stabilization without decompression group, and 16.7% in the radiotherapy group. There was no significant factor influencing the development of paralysis. |
| first_indexed | 2024-04-11T20:46:15Z |
| format | Article |
| id | doaj.art-6acaf490ae4c4789b60845f4418a6c70 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T20:46:15Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-6acaf490ae4c4789b60845f4418a6c702022-12-22T04:04:00ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2019-09-011411710.1186/s13018-019-1348-xNeurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumorMasafumi Maseda0Hiroshi Uei1Masahiro Nakahashi2Hirokatsu Sawada3Yasuaki Tokuhashi4Department of Orthopaedic Surgery, Nihon University School of MedicineDepartment of Orthopaedic Surgery, Nihon University School of MedicineDepartment of Orthopaedic Surgery, Nihon University School of MedicineDepartment of Orthopaedic Surgery, Nihon University School of MedicineDepartment of Orthopaedic Surgery, Nihon University School of MedicineAbstract Background Therapeutic intervention has recently been actively performed for metastatic spine tumor even though spinal cord paralysis is not clearly observed, but there has been no report in which the degree of spinal cord compression by tumor was taken into consideration for the paralysis-preventing effect of treatment. Thus, we investigated the neurological outcome after treatment of patients with spinal cord compression in a state of impending paralysis. Methods A retrospective cohort study. The subjects were 88 patients with epidural spinal cord compression (ESCC) scale 1b or severer compression with American Spinal Injury Association (ASIA) E spinal metastasis. The neurological outcome after the therapeutic intervention was investigated at regular intervals until death. The therapeutic intervention was posterior decompression and stabilization in 18 patients, stabilization without posterior decompression in 15, and radiotherapy in 55 patients (3 groups). Results The ASIA aggravation group was comprised of 15 patients, and the severity of paralysis was ASIA A in 3, B in 3, C in 6, and D in 3. Paralysis appeared in 16.7% in the posterior decompression and stabilization group, 13.3% in the posterior stabilization without decompression group, and 18.8% in the radiotherapy group. In the transverse view, the incidence was high in cases with advancement to the intervertebral foramen and circumferential-type advancement, and paralysis developed in more than 20% of ESCC 1c or severer cases. Factors influencing neurological aggravation were investigated, but there was no significant factor. Conclusion In ESCC 1b or severer cases with ASIA E spinal metastasis, paralysis aggravated after therapeutic intervention in 16.7% in the posterior decompression and stabilization group, 13.3% in the stabilization without decompression group, and 16.7% in the radiotherapy group. There was no significant factor influencing the development of paralysis.http://link.springer.com/article/10.1186/s13018-019-1348-xMetastatic spine tumorEpidural spinal cord compressionParalysisRadiotherapySurgery |
| spellingShingle | Masafumi Maseda Hiroshi Uei Masahiro Nakahashi Hirokatsu Sawada Yasuaki Tokuhashi Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor Journal of Orthopaedic Surgery and Research Metastatic spine tumor Epidural spinal cord compression Paralysis Radiotherapy Surgery |
| title | Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| title_full | Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| title_fullStr | Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| title_full_unstemmed | Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| title_short | Neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| title_sort | neurological outcome of treatment for patients with impending paralysis due to epidural spinal cord compression by metastatic spinal tumor |
| topic | Metastatic spine tumor Epidural spinal cord compression Paralysis Radiotherapy Surgery |
| url | http://link.springer.com/article/10.1186/s13018-019-1348-x |
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