c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease

c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer’s disease

BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer’s disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance decline of APPSwe/PSEN1ΔE9 (APP/PS1) mouse model for AD.MethodsWe used the co...

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Dettagli Bibliografici
Autori principali: Rilda León, Daniela A. Gutiérrez, Claudio Pinto, Cristian Morales, Catalina de la Fuente, Cristóbal Riquelme, Bastián I. Cortés, Adrián González-Martin, David Chamorro, Nelson Espinosa, Pablo Fuentealba, Gonzalo I. Cancino, Silvana Zanlungo, Andrés E. Dulcey, Juan J. Marugan, Alejandra Álvarez Rojas
Natura: Articolo
Lingua:English
Pubblicazione: Frontiers Media S.A. 2023-06-01
Serie:Frontiers in Aging Neuroscience
Soggetti:
c-Abl inhibitors
tyrosine kinases
Alzheimer’s disease
memory
Hippocampi
Accesso online:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1180987/full

Accesso online

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1180987/full

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