New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs
MiRNAs regulate both physiological and pathological heart functions. Altered expression of miRNAs is associated with cardiovascular diseases (CVDs), making miRNAs attractive therapeutic strategies for the diagnosis and treatment of heart diseases. A recent publication defined, for the first time, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6781 |
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| author | Francesco Sessa Monica Salerno Massimiliano Esposito Giuseppe Cocimano Daniela Pisanelli Abdul Malik Azmat Ali Khan Cristoforo Pomara |
| author_facet | Francesco Sessa Monica Salerno Massimiliano Esposito Giuseppe Cocimano Daniela Pisanelli Abdul Malik Azmat Ali Khan Cristoforo Pomara |
| author_sort | Francesco Sessa |
| collection | DOAJ |
| description | MiRNAs regulate both physiological and pathological heart functions. Altered expression of miRNAs is associated with cardiovascular diseases (CVDs), making miRNAs attractive therapeutic strategies for the diagnosis and treatment of heart diseases. A recent publication defined, for the first time, the term theranoMiRNA, meaning the miRNAs that may be used both for diagnosis and treatment. The use of in silico tools may be considered fundamental for these purposes, clarifying several molecular aspects, suggesting future directions for in vivo studies. This study aims to explore different bioinformatic tools in order to clarify miRNA interactions with candidate genes, demonstrating the need to use a computational approach when establishing the most probable associations between miRNAs and target genes. This study focused on the functions of miR-133a-3p, miR-21-5p, miR-499a-5p, miR-1-3p, and miR-126-3p, providing an up-to-date overview, and suggests future lines of research in the identification of theranoMiRNAs related to CVDs. Based on the results of the present study, we elucidated the molecular mechanisms that could be linked between miRNAs and CVDs, confirming that these miRNAs play an active role in the genesis and development of heart damage. Given that CVDs are the leading cause of death in the world, the identification of theranoMiRNAs is crucial, hence the need for a definition of in vivo studies in order to obtain further evidence in this challenging field of research. |
| first_indexed | 2024-03-11T05:33:49Z |
| format | Article |
| id | doaj.art-6ad1033a61ce4cb7a9570a9624dff045 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:33:49Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6ad1033a61ce4cb7a9570a9624dff0452023-11-17T16:55:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247678110.3390/ijms24076781New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAsFrancesco Sessa0Monica Salerno1Massimiliano Esposito2Giuseppe Cocimano3Daniela Pisanelli4Abdul Malik5Azmat Ali Khan6Cristoforo Pomara7Department of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95121 Catania, ItalyDepartment of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95121 Catania, ItalyDepartment of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95121 Catania, ItalyDepartment of Mental and Physical Health and Preventive Medicine, University of Campania “Vanvitelli”, 80121 Napoli, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaPharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Medical, Surgical and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95121 Catania, ItalyMiRNAs regulate both physiological and pathological heart functions. Altered expression of miRNAs is associated with cardiovascular diseases (CVDs), making miRNAs attractive therapeutic strategies for the diagnosis and treatment of heart diseases. A recent publication defined, for the first time, the term theranoMiRNA, meaning the miRNAs that may be used both for diagnosis and treatment. The use of in silico tools may be considered fundamental for these purposes, clarifying several molecular aspects, suggesting future directions for in vivo studies. This study aims to explore different bioinformatic tools in order to clarify miRNA interactions with candidate genes, demonstrating the need to use a computational approach when establishing the most probable associations between miRNAs and target genes. This study focused on the functions of miR-133a-3p, miR-21-5p, miR-499a-5p, miR-1-3p, and miR-126-3p, providing an up-to-date overview, and suggests future lines of research in the identification of theranoMiRNAs related to CVDs. Based on the results of the present study, we elucidated the molecular mechanisms that could be linked between miRNAs and CVDs, confirming that these miRNAs play an active role in the genesis and development of heart damage. Given that CVDs are the leading cause of death in the world, the identification of theranoMiRNAs is crucial, hence the need for a definition of in vivo studies in order to obtain further evidence in this challenging field of research.https://www.mdpi.com/1422-0067/24/7/6781microRNAs (miRNAs)cardiovascular diseases (CVD)myocardial infarctionheart damageheart failuretheranoMiRNAs |
| spellingShingle | Francesco Sessa Monica Salerno Massimiliano Esposito Giuseppe Cocimano Daniela Pisanelli Abdul Malik Azmat Ali Khan Cristoforo Pomara New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs International Journal of Molecular Sciences microRNAs (miRNAs) cardiovascular diseases (CVD) myocardial infarction heart damage heart failure theranoMiRNAs |
| title | New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs |
| title_full | New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs |
| title_fullStr | New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs |
| title_full_unstemmed | New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs |
| title_short | New Insight into Mechanisms of Cardiovascular Diseases: An Integrative Analysis Approach to Identify TheranoMiRNAs |
| title_sort | new insight into mechanisms of cardiovascular diseases an integrative analysis approach to identify theranomirnas |
| topic | microRNAs (miRNAs) cardiovascular diseases (CVD) myocardial infarction heart damage heart failure theranoMiRNAs |
| url | https://www.mdpi.com/1422-0067/24/7/6781 |
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