Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer
Genomic alterations and aberrant DNA damage signaling are hallmarks of ovarian cancer (OC), the leading cause of mortality among gynecological cancers worldwide. Owing to the lack of specific symptoms and late-stage diagnosis, survival chances of patients are significantly reduced. Poly (ADP-ribose)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/11/2690 |
| _version_ | 1797532055933812736 |
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| author | Arkadiusz Gajek Patrycja Gralewska Agnieszka Marczak Aneta Rogalska |
| author_facet | Arkadiusz Gajek Patrycja Gralewska Agnieszka Marczak Aneta Rogalska |
| author_sort | Arkadiusz Gajek |
| collection | DOAJ |
| description | Genomic alterations and aberrant DNA damage signaling are hallmarks of ovarian cancer (OC), the leading cause of mortality among gynecological cancers worldwide. Owing to the lack of specific symptoms and late-stage diagnosis, survival chances of patients are significantly reduced. Poly (ADP-ribose) polymerase (PARP) inhibitors and replication stress response inhibitors present attractive therapeutic strategies for OC. Recent research has focused on ovarian cancer-associated microRNAs (miRNAs) that play significant regulatory roles in various cellular processes. While miRNAs have been shown to participate in regulation of tumorigenesis and drug responses through modulating the DNA damage response (DDR), little is known about their potential influence on sensitivity to chemotherapy. The main objective of this review is to summarize recent findings on the utility of miRNAs as cancer biomarkers, in particular, ovarian cancer, and their regulation of DDR or modified replication stress response proteins. We further discuss the suppressive and promotional effects of various miRNAs on ovarian cancer and their participation in cell cycle disturbance, response to DNA damage, and therapeutic functions in multiple cancer types, with particular focus on ovarian cancer. Improved understanding of the mechanisms by which miRNAs regulate drug resistance should facilitate the development of effective combination therapies for ovarian cancer. |
| first_indexed | 2024-03-10T10:53:37Z |
| format | Article |
| id | doaj.art-6ad24262db524462b667cf6a2d63147e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:53:37Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6ad24262db524462b667cf6a2d63147e2023-11-21T22:03:10ZengMDPI AGCancers2072-66942021-05-011311269010.3390/cancers13112690Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian CancerArkadiusz Gajek0Patrycja Gralewska1Agnieszka Marczak2Aneta Rogalska3Department of Medical Biophysics, Faculty of Biology and Environmental Protection, Institute of Biophysics, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Medical Biophysics, Faculty of Biology and Environmental Protection, Institute of Biophysics, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Medical Biophysics, Faculty of Biology and Environmental Protection, Institute of Biophysics, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandDepartment of Medical Biophysics, Faculty of Biology and Environmental Protection, Institute of Biophysics, University of Lodz, Pomorska 141/143, 90-236 Lodz, PolandGenomic alterations and aberrant DNA damage signaling are hallmarks of ovarian cancer (OC), the leading cause of mortality among gynecological cancers worldwide. Owing to the lack of specific symptoms and late-stage diagnosis, survival chances of patients are significantly reduced. Poly (ADP-ribose) polymerase (PARP) inhibitors and replication stress response inhibitors present attractive therapeutic strategies for OC. Recent research has focused on ovarian cancer-associated microRNAs (miRNAs) that play significant regulatory roles in various cellular processes. While miRNAs have been shown to participate in regulation of tumorigenesis and drug responses through modulating the DNA damage response (DDR), little is known about their potential influence on sensitivity to chemotherapy. The main objective of this review is to summarize recent findings on the utility of miRNAs as cancer biomarkers, in particular, ovarian cancer, and their regulation of DDR or modified replication stress response proteins. We further discuss the suppressive and promotional effects of various miRNAs on ovarian cancer and their participation in cell cycle disturbance, response to DNA damage, and therapeutic functions in multiple cancer types, with particular focus on ovarian cancer. Improved understanding of the mechanisms by which miRNAs regulate drug resistance should facilitate the development of effective combination therapies for ovarian cancer.https://www.mdpi.com/2072-6694/13/11/2690microRNAovarian cancerPARPreplication stresstargeted therapy |
| spellingShingle | Arkadiusz Gajek Patrycja Gralewska Agnieszka Marczak Aneta Rogalska Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer Cancers microRNA ovarian cancer PARP replication stress targeted therapy |
| title | Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer |
| title_full | Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer |
| title_fullStr | Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer |
| title_full_unstemmed | Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer |
| title_short | Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer |
| title_sort | current implications of micrornas in genome stability and stress responses of ovarian cancer |
| topic | microRNA ovarian cancer PARP replication stress targeted therapy |
| url | https://www.mdpi.com/2072-6694/13/11/2690 |
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