Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis

Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis

Aims/Hypothesis: Fibroblast growth factor 21 (FGF21) is a hepatokine with pleiotropic effects on glucose and lipid metabolic homeostasis. Here, we aimed to elucidate the mechanisms underlying the protective effects of FGF21 on L-lactate homeostasis and liver lesions in a type 1 diabetes mellitus (T1...

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Bibliographic Details
Main Authors: Jiapin Yan, Jiaojiao Xie, Sibei Xu, Yuejun Guo, Keru Ji, Chen Li, Hongchang Gao, Liangcai Zhao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Type 1 diabetic mellitus
Liver injury
FGF21
Cori cycle
MCT2
HCA1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223015354

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