CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis
Tuberculosis (TB) is a serious lung infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis) is highly contagious, and can be spread through the air from an infected person to others. The aim of this article was to evaluate the immunological role of CD4 and CD20 in patients inf...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | E3S Web of Conferences |
| Subjects: | |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/26/e3sconf_uesf2023_03108.pdf |
| _version_ | 1827930046313005056 |
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| author | Kamoona Firas Mohammad Hussein Aljanaby Ahmed Abduljabbar Jaloob |
| author_facet | Kamoona Firas Mohammad Hussein Aljanaby Ahmed Abduljabbar Jaloob |
| author_sort | Kamoona Firas Mohammad Hussein |
| collection | DOAJ |
| description | Tuberculosis (TB) is a serious lung infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis) is highly contagious, and can be spread through the air from an infected person to others. The aim of this article was to evaluate the immunological role of CD4 and CD20 in patients infected with M. tuberculosis and multi-drug resistant tuberculosis (MDRTB). A total of 182 individuals suspected with M. tuberculosis admitted to the tuberculosis center in AL-Najaf City, Iraq. A sputum acid-fast stain was performed for each individual and GeneXpert® heminested real time PCR has been performed for MDR-M. tuberculosis detection. CD4 and CD20 have been measurement in serum of infected individual using ELISA technique. Serum CD4 and CD20 levels were significantly elevated (P<0.05) in patients with M. tuberculosis and MDR-M. tuberculosis groups as compared with control subjects. The MDRTB group showed higher serum CD4 and CD20 levels (P<0.05) than the M. tuberculosis group. This study showed that CD4 and CD20 had a relationship with M. tuberculosis and might be used to help diagnose TB. |
| first_indexed | 2024-03-13T06:30:54Z |
| format | Article |
| id | doaj.art-6ad5503d7ab04d8f9903215fade17ae9 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-03-13T06:30:54Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-6ad5503d7ab04d8f9903215fade17ae92023-06-09T09:08:38ZengEDP SciencesE3S Web of Conferences2267-12422023-01-013890310810.1051/e3sconf/202338903108e3sconf_uesf2023_03108CD4 and CD20 as important immune markers in patients with pulmonary tuberculosisKamoona Firas Mohammad Hussein0Aljanaby Ahmed Abduljabbar Jaloob1Department of Biology, Faculty of Science, University of KufaDepartment of Biology, Faculty of Science, University of KufaTuberculosis (TB) is a serious lung infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis) is highly contagious, and can be spread through the air from an infected person to others. The aim of this article was to evaluate the immunological role of CD4 and CD20 in patients infected with M. tuberculosis and multi-drug resistant tuberculosis (MDRTB). A total of 182 individuals suspected with M. tuberculosis admitted to the tuberculosis center in AL-Najaf City, Iraq. A sputum acid-fast stain was performed for each individual and GeneXpert® heminested real time PCR has been performed for MDR-M. tuberculosis detection. CD4 and CD20 have been measurement in serum of infected individual using ELISA technique. Serum CD4 and CD20 levels were significantly elevated (P<0.05) in patients with M. tuberculosis and MDR-M. tuberculosis groups as compared with control subjects. The MDRTB group showed higher serum CD4 and CD20 levels (P<0.05) than the M. tuberculosis group. This study showed that CD4 and CD20 had a relationship with M. tuberculosis and might be used to help diagnose TB.https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/26/e3sconf_uesf2023_03108.pdfcd4cd20tbmtbmdrmtbgenexpert |
| spellingShingle | Kamoona Firas Mohammad Hussein Aljanaby Ahmed Abduljabbar Jaloob CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis E3S Web of Conferences cd4 cd20 tb mtb mdrmtb genexpert |
| title | CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis |
| title_full | CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis |
| title_fullStr | CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis |
| title_full_unstemmed | CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis |
| title_short | CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis |
| title_sort | cd4 and cd20 as important immune markers in patients with pulmonary tuberculosis |
| topic | cd4 cd20 tb mtb mdrmtb genexpert |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2023/26/e3sconf_uesf2023_03108.pdf |
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