T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus
The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01027/full |
| _version_ | 1818282675834716160 |
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| author | Juan Shan Hong Jin Yan Xu |
| author_facet | Juan Shan Hong Jin Yan Xu |
| author_sort | Juan Shan |
| collection | DOAJ |
| description | The Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism influences and reprograms the Th17/Treg cell balance, and the metabolic pattern of T cells is different in SLE. Notably, metabolic characteristics of SLE T cells, such as enhanced glycolysis, lipid synthesis, glutaminolysis, and highly activated mTOR, all favored Th17 differentiation and function, which underlie the Th17/Treg cell imbalance in SLE patients. Targeting metabolic pathways to reverse Th17/Treg imbalance offer a promising method for SLE therapy. |
| first_indexed | 2024-12-13T00:24:47Z |
| format | Article |
| id | doaj.art-6ad70b730b424cb386b2bdf9e20f0969 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T00:24:47Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6ad70b730b424cb386b2bdf9e20f09692022-12-22T00:05:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.01027542018T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus ErythematosusJuan ShanHong JinYan XuThe Th17/T-regulatory (Treg) cell imbalance is involved in the occurrence and development of organ inflammation in systemic lupus erythematosus (SLE). Metabolic pathways can regulate T cell differentiation and function, thus contributing to SLE inflammation. Increasingly, data have shown metabolism influences and reprograms the Th17/Treg cell balance, and the metabolic pattern of T cells is different in SLE. Notably, metabolic characteristics of SLE T cells, such as enhanced glycolysis, lipid synthesis, glutaminolysis, and highly activated mTOR, all favored Th17 differentiation and function, which underlie the Th17/Treg cell imbalance in SLE patients. Targeting metabolic pathways to reverse Th17/Treg imbalance offer a promising method for SLE therapy.https://www.frontiersin.org/article/10.3389/fimmu.2020.01027/fullcell metabolismT helper 17 cellsregulatory T cellssystemic lupus erythematosusmTOR signaling |
| spellingShingle | Juan Shan Hong Jin Yan Xu T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus Frontiers in Immunology cell metabolism T helper 17 cells regulatory T cells systemic lupus erythematosus mTOR signaling |
| title | T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus |
| title_full | T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus |
| title_fullStr | T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus |
| title_full_unstemmed | T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus |
| title_short | T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus |
| title_sort | t cell metabolism a new perspective on th17 treg cell imbalance in systemic lupus erythematosus |
| topic | cell metabolism T helper 17 cells regulatory T cells systemic lupus erythematosus mTOR signaling |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01027/full |
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