Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions
Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of &...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/4/726 |
| _version_ | 1819135189827190784 |
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| author | Elisabetta Massolo Margherita Pirola Sergio Rossi Tiziana Benincori |
| author_facet | Elisabetta Massolo Margherita Pirola Sergio Rossi Tiziana Benincori |
| author_sort | Elisabetta Massolo |
| collection | DOAJ |
| description | Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF<sub>3</sub> substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF<sub>3</sub> species. We also implemented an in-flow protocol to improve the safety features of the process. |
| first_indexed | 2024-12-22T10:15:08Z |
| format | Article |
| id | doaj.art-6ad8758dd02c41259dc0c7ce3e13f88a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T10:15:08Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6ad8758dd02c41259dc0c7ce3e13f88a2022-12-21T18:29:44ZengMDPI AGMolecules1420-30492019-02-0124472610.3390/molecules24040726molecules24040726Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow ConditionsElisabetta Massolo0Margherita Pirola1Sergio Rossi2Tiziana Benincori3Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, ItalyDipartimento di Scienza e Alta Tecnologia, Università degli Studi Dell’Insubria, Via Valleggio 11, 22100 Como, ItalyTrifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF<sub>3</sub> substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF<sub>3</sub> species. We also implemented an in-flow protocol to improve the safety features of the process.https://www.mdpi.com/1420-3049/24/4/726trifluoromethylselenolationcarbonyl compoundsseleniumfluorinated derivativesflow chemistry |
| spellingShingle | Elisabetta Massolo Margherita Pirola Sergio Rossi Tiziana Benincori Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions Molecules trifluoromethylselenolation carbonyl compounds selenium fluorinated derivatives flow chemistry |
| title | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
| title_full | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
| title_fullStr | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
| title_full_unstemmed | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
| title_short | Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions |
| title_sort | metal free alpha trifluoromethylselenolation of carbonyl derivatives under batch and flow conditions |
| topic | trifluoromethylselenolation carbonyl compounds selenium fluorinated derivatives flow chemistry |
| url | https://www.mdpi.com/1420-3049/24/4/726 |
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