The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans

Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Therefore, this study aimed to investigate the positive effect of Camellia oleifera oil (CO) on the lifespan of C. elegans through transcriptome and metabolome analysis. The results demonstrated th...

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Main Authors: Li Liu, Jiasi Zhou, Zhou Xu, Qingbo Kong, Jie Zhang, Heng Wang, Zhuoya Xiang, Tao Chen, Lijun Zhou, Shiling Feng, Hongyu Yang, Yan Huang, Chunbang Ding.
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Journal of Functional Foods
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464623004693
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author Li Liu
Jiasi Zhou
Zhou Xu
Qingbo Kong
Jie Zhang
Heng Wang
Zhuoya Xiang
Tao Chen
Lijun Zhou
Shiling Feng
Hongyu Yang
Yan Huang
Chunbang Ding.
author_facet Li Liu
Jiasi Zhou
Zhou Xu
Qingbo Kong
Jie Zhang
Heng Wang
Zhuoya Xiang
Tao Chen
Lijun Zhou
Shiling Feng
Hongyu Yang
Yan Huang
Chunbang Ding.
author_sort Li Liu
collection DOAJ
description Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Therefore, this study aimed to investigate the positive effect of Camellia oleifera oil (CO) on the lifespan of C. elegans through transcriptome and metabolome analysis. The results demonstrated that CO direct significantly increased the lifespan and mean lifespan to 25.00 and 18.43 d, respectively, compared to the control group (15.95 d). Moreover, CO supplementation significantly improved the healthspan of C. elegans. Additionally, CO altered the transcription levels of genes involved in longevity regulating pathway and activated stress resistance pathway and influenced the levels of metabolic biomarkers related to galactose metabolism. Additionally, CO significantly reduced the content of ROS and MDA in C. elegans by 21.54% and 42.40%, respectively. Together, the study highlights the potential of CO in promoting lifespan and improving the health status, which shall facilitate its further development in the food and pharmaceutical industries.
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spelling doaj.art-6ad95c8f15b5400d93f2665de7060ef52023-11-10T04:16:16ZengElsevierJournal of Functional Foods1756-46462023-11-01110105869The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegansLi Liu0Jiasi Zhou1Zhou Xu2Qingbo Kong3Jie Zhang4Heng Wang5Zhuoya Xiang6Tao Chen7Lijun Zhou8Shiling Feng9Hongyu Yang10Yan Huang11Chunbang Ding.12College of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaPanxi Crops Research and Utilization Key Laboratory of Sichuan Province, Xichang University, Xichang 615000, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, China; Institute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, ChinaCollege of Life Science, Sichuan Agricultural University, Ya’an 625014, China; Corresponding author.Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Therefore, this study aimed to investigate the positive effect of Camellia oleifera oil (CO) on the lifespan of C. elegans through transcriptome and metabolome analysis. The results demonstrated that CO direct significantly increased the lifespan and mean lifespan to 25.00 and 18.43 d, respectively, compared to the control group (15.95 d). Moreover, CO supplementation significantly improved the healthspan of C. elegans. Additionally, CO altered the transcription levels of genes involved in longevity regulating pathway and activated stress resistance pathway and influenced the levels of metabolic biomarkers related to galactose metabolism. Additionally, CO significantly reduced the content of ROS and MDA in C. elegans by 21.54% and 42.40%, respectively. Together, the study highlights the potential of CO in promoting lifespan and improving the health status, which shall facilitate its further development in the food and pharmaceutical industries.http://www.sciencedirect.com/science/article/pii/S1756464623004693Camellia oleifera oilCaenorhabditis elegansLifespanTranscriptomicsMetabolomics
spellingShingle Li Liu
Jiasi Zhou
Zhou Xu
Qingbo Kong
Jie Zhang
Heng Wang
Zhuoya Xiang
Tao Chen
Lijun Zhou
Shiling Feng
Hongyu Yang
Yan Huang
Chunbang Ding.
The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
Journal of Functional Foods
Camellia oleifera oil
Caenorhabditis elegans
Lifespan
Transcriptomics
Metabolomics
title The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
title_full The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
title_fullStr The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
title_full_unstemmed The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
title_short The positive effects of Camellia oleifera oil on lifespan in Caenorhabditis elegans
title_sort positive effects of camellia oleifera oil on lifespan in caenorhabditis elegans
topic Camellia oleifera oil
Caenorhabditis elegans
Lifespan
Transcriptomics
Metabolomics
url http://www.sciencedirect.com/science/article/pii/S1756464623004693
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