Enhanced AKT phosphorylation of circulating B cells in patients with activated PI3Kδ syndrome

Enhanced AKT phosphorylation of circulating B cells in patients with activated PI3Kδ syndrome

Activated PI3Kδ syndrome (APDS) is a primary immunodeficiency characterized by recurrent respiratory tract infections, lymphoproliferation, and defective IgG production. Heterozygous mutations in PIK3CD, PIK3R1, or PTEN, which are related to the hyperactive phosphoinositide 3-kinase (PI3K) signaling...

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Bibliographic Details
Main Authors:	Osamu Ohara, Kohsuke Imai, Taizo Wada, Kunio Hashimoto, Akira Shimada, Kanako Mitsui-Sekinaka, Tzu-Wen Yeh, Takaki Asano, Youjiro Ichinose
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Series:	Frontiers in Immunology
Subjects:	Flow Cytometry immunodeficiency Akt phosphorylation Activated PI3 kinase delta syndrome catalytic subunit p110δ of phosphatidylinositol 3-kinase regulatory subunit p85α of phosphatidylinositol 3-kinase
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2018.00568/full

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