Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis
Hepatic fibrosis is now regarded as a common response to chronic liver injury; regardless of its nature (viral infections, alcohol abuse and metal overload). It is also characterized by excessive deposition of extracellular matrix (ECM) components. The ECM is a dynamic complex of macromolecules that...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hamad Bin Khalifa University Press
2013-06-01
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| Series: | QScience Connect |
| Online Access: | http://www.qscience.com/doi/pdf/10.5339/connect.2013.17 |
| _version_ | 1797970317991215104 |
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| author | Nilgün Tekkesin Yaz Taga Aydın Sav Süheyla Bozkurt |
| author_facet | Nilgün Tekkesin Yaz Taga Aydın Sav Süheyla Bozkurt |
| author_sort | Nilgün Tekkesin |
| collection | DOAJ |
| description | Hepatic fibrosis is now regarded as a common response to chronic liver injury; regardless of its nature (viral infections, alcohol abuse and metal overload). It is also characterized by excessive deposition of extracellular matrix (ECM) components. The ECM is a dynamic complex of macromolecules that includes collagens, glycoproteins, and proteoglycans, such as laminin and fibronectin; it has been shown that it does not only support the tissue structure, but also plays a major role in cell adhesion, proliferation, and differentiation. Remodelling of the ECM may be the signal that facilitates lobular reorganization during liver regeneration after a liver injury. Much work has been done concerning the ECM synthesis and protein contents. |
| first_indexed | 2024-04-11T03:16:03Z |
| format | Article |
| id | doaj.art-6adaa52b01a642989baab73b0ef07c6b |
| institution | Directory Open Access Journal |
| issn | 2223-506X |
| language | English |
| last_indexed | 2024-04-11T03:16:03Z |
| publishDate | 2013-06-01 |
| publisher | Hamad Bin Khalifa University Press |
| record_format | Article |
| series | QScience Connect |
| spelling | doaj.art-6adaa52b01a642989baab73b0ef07c6b2023-01-02T10:28:22ZengHamad Bin Khalifa University PressQScience Connect2223-506X2013-06-012013110.5339/connect.2013.17Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosisNilgün TekkesinYaz TagaAydın SavSüheyla BozkurtHepatic fibrosis is now regarded as a common response to chronic liver injury; regardless of its nature (viral infections, alcohol abuse and metal overload). It is also characterized by excessive deposition of extracellular matrix (ECM) components. The ECM is a dynamic complex of macromolecules that includes collagens, glycoproteins, and proteoglycans, such as laminin and fibronectin; it has been shown that it does not only support the tissue structure, but also plays a major role in cell adhesion, proliferation, and differentiation. Remodelling of the ECM may be the signal that facilitates lobular reorganization during liver regeneration after a liver injury. Much work has been done concerning the ECM synthesis and protein contents.http://www.qscience.com/doi/pdf/10.5339/connect.2013.17 |
| spellingShingle | Nilgün Tekkesin Yaz Taga Aydın Sav Süheyla Bozkurt Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis QScience Connect |
| title | Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis |
| title_full | Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis |
| title_fullStr | Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis |
| title_full_unstemmed | Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis |
| title_short | Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis |
| title_sort | modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced kuffer cell blockade in an experimental model of liver fibrosis cirrhosis |
| url | http://www.qscience.com/doi/pdf/10.5339/connect.2013.17 |
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