Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation
To validate range shifts in proton therapy, we investigated the potential of using the temporal information of prompt gamma rays as an indicator. We simulated the proton transport process using Monte Carlo simulations and used a geometric scorer to obtain the location and timing of prompt gamma ray...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Physics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphy.2024.1295683/full |
| _version_ | 1797306999680008192 |
|---|---|
| author | Yibo He Yibo He Xin Tong Yuhan Li Jingyi Cheng Rong Zhou Rong Zhou |
| author_facet | Yibo He Yibo He Xin Tong Yuhan Li Jingyi Cheng Rong Zhou Rong Zhou |
| author_sort | Yibo He |
| collection | DOAJ |
| description | To validate range shifts in proton therapy, we investigated the potential of using the temporal information of prompt gamma rays as an indicator. We simulated the proton transport process using Monte Carlo simulations and used a geometric scorer to obtain the location and timing of prompt gamma ray production. By using a homogeneous target material in the simulation model, we established a fitted relationship between the range of 90–210 MeV protons and the corresponding temporal spectral width. Additionally, by introducing air cavities of 2–20 mm in simulations of inhomogeneous target materials, we observed significant correlations between the range offsets and the temporal spectral widths. These correlations were fitted to derive a functional relationship between the two variables. |
| first_indexed | 2024-03-08T00:51:00Z |
| format | Article |
| id | doaj.art-6adb8f76bf9f46e292dcab8b0ab3b588 |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-03-08T00:51:00Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-6adb8f76bf9f46e292dcab8b0ab3b5882024-02-15T04:28:40ZengFrontiers Media S.A.Frontiers in Physics2296-424X2024-02-011210.3389/fphy.2024.12956831295683Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulationYibo He0Yibo He1Xin Tong2Yuhan Li3Jingyi Cheng4Rong Zhou5Rong Zhou6College of Physics, Sichuan University, Chengdu, ChinaMOE Key Laboratory of Radiation Physics and Technology, Sichuan University, Chengdu, ChinaCollege of Physics, Sichuan University, Chengdu, ChinaCollege of Physics, Sichuan University, Chengdu, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaCollege of Physics, Sichuan University, Chengdu, ChinaMOE Key Laboratory of Radiation Physics and Technology, Sichuan University, Chengdu, ChinaTo validate range shifts in proton therapy, we investigated the potential of using the temporal information of prompt gamma rays as an indicator. We simulated the proton transport process using Monte Carlo simulations and used a geometric scorer to obtain the location and timing of prompt gamma ray production. By using a homogeneous target material in the simulation model, we established a fitted relationship between the range of 90–210 MeV protons and the corresponding temporal spectral width. Additionally, by introducing air cavities of 2–20 mm in simulations of inhomogeneous target materials, we observed significant correlations between the range offsets and the temporal spectral widths. These correlations were fitted to derive a functional relationship between the two variables.https://www.frontiersin.org/articles/10.3389/fphy.2024.1295683/fullproton therapyrange verificationprompt gamma-ray timingMonte Carlo simulationtime of flight |
| spellingShingle | Yibo He Yibo He Xin Tong Yuhan Li Jingyi Cheng Rong Zhou Rong Zhou Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation Frontiers in Physics proton therapy range verification prompt gamma-ray timing Monte Carlo simulation time of flight |
| title | Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation |
| title_full | Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation |
| title_fullStr | Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation |
| title_full_unstemmed | Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation |
| title_short | Establishing the function relationship between time spectrum and proton range in proton therapy through Monte Carlo simulation |
| title_sort | establishing the function relationship between time spectrum and proton range in proton therapy through monte carlo simulation |
| topic | proton therapy range verification prompt gamma-ray timing Monte Carlo simulation time of flight |
| url | https://www.frontiersin.org/articles/10.3389/fphy.2024.1295683/full |
| work_keys_str_mv | AT yibohe establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT yibohe establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT xintong establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT yuhanli establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT jingyicheng establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT rongzhou establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation AT rongzhou establishingthefunctionrelationshipbetweentimespectrumandprotonrangeinprotontherapythroughmontecarlosimulation |