Artificial Oocyte: Development and Potential Application
Millions of people around the world suffer from infertility, with the number of infertile couples and individuals increasing every year. Assisted reproductive technologies (ART) have been widely developed in recent years; however, some patients are unable to benefit from these technologies due to th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/7/1135 |
| _version_ | 1797439912544305152 |
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| author | Reza K. Oqani Seongjun So Yeonmi Lee Jung Jae Ko Eunju Kang |
| author_facet | Reza K. Oqani Seongjun So Yeonmi Lee Jung Jae Ko Eunju Kang |
| author_sort | Reza K. Oqani |
| collection | DOAJ |
| description | Millions of people around the world suffer from infertility, with the number of infertile couples and individuals increasing every year. Assisted reproductive technologies (ART) have been widely developed in recent years; however, some patients are unable to benefit from these technologies due to their lack of functional germ cells. Therefore, the development of alternative methods seems necessary. One of these methods is to create artificial oocytes. Oocytes can be generated in vitro from the ovary, fetal gonad, germline stem cells (GSCs), ovarian stem cells, or pluripotent stem cells (PSCs). This approach has raised new hopes in both basic research and medical applications. In this article, we looked at the principle of oocyte development, the landmark studies that enhanced our understanding of the cellular and molecular mechanisms that govern oogenesis in vivo, as well as the mechanisms underlying in vitro generation of functional oocytes from different sources of mouse and human stem cells. In addition, we introduced next-generation ART using somatic cells with artificial oocytes. Finally, we provided an overview of the reproductive application of in vitro oogenesis and its use in human fertility. |
| first_indexed | 2024-03-09T12:00:36Z |
| format | Article |
| id | doaj.art-6add534753414020b712c8623b827c66 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:00:36Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6add534753414020b712c8623b827c662023-11-30T23:03:58ZengMDPI AGCells2073-44092022-03-01117113510.3390/cells11071135Artificial Oocyte: Development and Potential ApplicationReza K. Oqani0Seongjun So1Yeonmi Lee2Jung Jae Ko3Eunju Kang4Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, KoreaDepartment of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, KoreaMillions of people around the world suffer from infertility, with the number of infertile couples and individuals increasing every year. Assisted reproductive technologies (ART) have been widely developed in recent years; however, some patients are unable to benefit from these technologies due to their lack of functional germ cells. Therefore, the development of alternative methods seems necessary. One of these methods is to create artificial oocytes. Oocytes can be generated in vitro from the ovary, fetal gonad, germline stem cells (GSCs), ovarian stem cells, or pluripotent stem cells (PSCs). This approach has raised new hopes in both basic research and medical applications. In this article, we looked at the principle of oocyte development, the landmark studies that enhanced our understanding of the cellular and molecular mechanisms that govern oogenesis in vivo, as well as the mechanisms underlying in vitro generation of functional oocytes from different sources of mouse and human stem cells. In addition, we introduced next-generation ART using somatic cells with artificial oocytes. Finally, we provided an overview of the reproductive application of in vitro oogenesis and its use in human fertility.https://www.mdpi.com/2073-4409/11/7/1135assisted reproductive technologiesartificial oocyteoogenesisstem cellshaploidization of somatic chromosomes |
| spellingShingle | Reza K. Oqani Seongjun So Yeonmi Lee Jung Jae Ko Eunju Kang Artificial Oocyte: Development and Potential Application Cells assisted reproductive technologies artificial oocyte oogenesis stem cells haploidization of somatic chromosomes |
| title | Artificial Oocyte: Development and Potential Application |
| title_full | Artificial Oocyte: Development and Potential Application |
| title_fullStr | Artificial Oocyte: Development and Potential Application |
| title_full_unstemmed | Artificial Oocyte: Development and Potential Application |
| title_short | Artificial Oocyte: Development and Potential Application |
| title_sort | artificial oocyte development and potential application |
| topic | assisted reproductive technologies artificial oocyte oogenesis stem cells haploidization of somatic chromosomes |
| url | https://www.mdpi.com/2073-4409/11/7/1135 |
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