MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea
Portable Near Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a novel entirely on-site approach for occupational exposure monitoring in pharmaceutical field. Due to a significant increase in the number of patients receiving chemotherapy, the development of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fchem.2018.00228/full |
| _version_ | 1819230351810101248 |
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| author | Roberta Risoluti Stefano Materazzi |
| author_facet | Roberta Risoluti Stefano Materazzi |
| author_sort | Roberta Risoluti |
| collection | DOAJ |
| description | Portable Near Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a novel entirely on-site approach for occupational exposure monitoring in pharmaceutical field. Due to a significant increase in the number of patients receiving chemotherapy, the development of reliable, fast, and on-site analytical methods to assess the occupational exposure of workers in the manufacture of pharmaceutical products, has become more and more required. In this work, a fast, accurate, and sensitive detection of hydroxyurea, a cytotoxic antineoplastic agent commonly used in chemotherapy, was developed. Occupational exposure to antineoplastic agents was evaluated by collecting hydroxyurea on a membrane filter during routine drug manufacturing process. Spectra were acquired in the NIR region in reflectance mode by the means of a miniaturized NIR spectrometer coupled with chemometrics. This MicroNIR instrument is a very ultra-compact portable device with a particular geometry and optical resolution designed in such a manner that the reduction in size does not compromise the performances of the spectrometer. The developed method could detect up to 50 ng of hydroxyurea directly measured on the sampling filter membrane, irrespective of complexity and variability of the matrix; thus extending the applicability of miniaturized NIR instruments in pharmaceutical and biomedical analysis. |
| first_indexed | 2024-12-23T11:27:42Z |
| format | Article |
| id | doaj.art-6add78f5a314442caa9fb85d7d3bc912 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-23T11:27:42Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-6add78f5a314442caa9fb85d7d3bc9122022-12-21T17:48:53ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462018-06-01610.3389/fchem.2018.00228365421MicroNIR/Chemometrics Assessement of Occupational Exposure to HydroxyureaRoberta RisolutiStefano MaterazziPortable Near Infrared spectroscopy (NIRs) coupled to chemometrics was investigated for the first time as a novel entirely on-site approach for occupational exposure monitoring in pharmaceutical field. Due to a significant increase in the number of patients receiving chemotherapy, the development of reliable, fast, and on-site analytical methods to assess the occupational exposure of workers in the manufacture of pharmaceutical products, has become more and more required. In this work, a fast, accurate, and sensitive detection of hydroxyurea, a cytotoxic antineoplastic agent commonly used in chemotherapy, was developed. Occupational exposure to antineoplastic agents was evaluated by collecting hydroxyurea on a membrane filter during routine drug manufacturing process. Spectra were acquired in the NIR region in reflectance mode by the means of a miniaturized NIR spectrometer coupled with chemometrics. This MicroNIR instrument is a very ultra-compact portable device with a particular geometry and optical resolution designed in such a manner that the reduction in size does not compromise the performances of the spectrometer. The developed method could detect up to 50 ng of hydroxyurea directly measured on the sampling filter membrane, irrespective of complexity and variability of the matrix; thus extending the applicability of miniaturized NIR instruments in pharmaceutical and biomedical analysis.https://www.frontiersin.org/article/10.3389/fchem.2018.00228/fullMicroNIRchemometricshydroxyureaoccupational exposurepharmaceutics |
| spellingShingle | Roberta Risoluti Stefano Materazzi MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea Frontiers in Chemistry MicroNIR chemometrics hydroxyurea occupational exposure pharmaceutics |
| title | MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea |
| title_full | MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea |
| title_fullStr | MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea |
| title_full_unstemmed | MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea |
| title_short | MicroNIR/Chemometrics Assessement of Occupational Exposure to Hydroxyurea |
| title_sort | micronir chemometrics assessement of occupational exposure to hydroxyurea |
| topic | MicroNIR chemometrics hydroxyurea occupational exposure pharmaceutics |
| url | https://www.frontiersin.org/article/10.3389/fchem.2018.00228/full |
| work_keys_str_mv | AT robertarisoluti micronirchemometricsassessementofoccupationalexposuretohydroxyurea AT stefanomaterazzi micronirchemometricsassessementofoccupationalexposuretohydroxyurea |