Objective assessment of optical quality in dry eye disease using a double-pass imaging system
Larissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Caroli...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2019-10-01
|
| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/objective-assessment-of-optical-quality-in-dry-eye-disease-using-a-dou-peer-reviewed-article-OPTH |
| _version_ | 1819021367806263296 |
|---|---|
| author | Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM |
| author_facet | Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM |
| author_sort | Gouvea L |
| collection | DOAJ |
| description | Larissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA; 4Department of Internal Medicine, Tulane University School of Medicine, New Orleans, LA, USACorrespondence: Larissa GouveaStorm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USAEmail gouveaalarissa@gmail.comPurpose: To assess optical quality dynamics using a double-pass (DP) system in patients with dry eye disease (DED).Methods: Seventy-six eyes with DED and 44 control subjects were enrolled in this study. Each patient underwent ocular surface evaluation including fluorescein corneal staining and Schirmer’s II test. Ocular Surface Disease Index (OSDI) questionnaire was used to assess subjective symptoms. Optical quality dynamics and tear film instability was analyzed using a DP system (HD AnalyzerTM, Visiometrics, Spain). Mean objective scatter index (OSI), maximum and minimum OSI, difference between maximum and minimum OSI (ΔOSI) were recorded with 40 consecutive scans over 20 s.Results: The DED group had pronounced impairment of optical quality compared to the control group. Mean OSI (4.29±4.07), minimum (3.22±3.51) and maximum (5.72±4.52) OSI, ΔOSI (2.50±1.96), OSDI score (36.94±16.55), and fluorescein corneal staining (0.79±0.96) were statistically significantly higher than controls (p<0.05). Schirmer’s II test was statistically significantly lower in the DED group compared to controls (10.08±7.85, 26.41±6.75, respectively; p<0.001). Three patterns of dynamic changes of OSI were proposed: ladder (continuous increase of OSI), seesaw (instability of OSI without improvement after blinking), and plateau (steady-high OSI). The ladder group showed the highest value of maximum OSI (6.93±4.13; p=0.03) and ΔOSI (3.76±2.08; p<0.001).Conclusion: DP imaging system provides an objective measurement of the visual quality in DED. Tear film instability may be assessed by dynamic changes of OSI over 20 s. In particular, the highest OSI values were observed in the ladder pattern group.Keywords: dry eye disease, quality of vision, tear film analysis, double-pass imaging system, objective scatter index, ocular surface disease index, fluorescein corneal staining, Schirmer’s test |
| first_indexed | 2024-12-21T04:05:59Z |
| format | Article |
| id | doaj.art-6adfeb27e236468fa457eac391086f0c |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-21T04:05:59Z |
| publishDate | 2019-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-6adfeb27e236468fa457eac391086f0c2022-12-21T19:16:36ZengDove Medical PressClinical Ophthalmology1177-54832019-10-01Volume 131991199649040Objective assessment of optical quality in dry eye disease using a double-pass imaging systemGouvea LWaring GO IVBrundrett ACrouse MRocha KMLarissa Gouvea,1 George Oral Waring IV,2 Ashley Brundrett,1,3 Michelle Crouse,4 Karolinne Maia Rocha1,3 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA; 2Waring Vision Institute, Mount Pleasant, SC, USA; 3Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, USA; 4Department of Internal Medicine, Tulane University School of Medicine, New Orleans, LA, USACorrespondence: Larissa GouveaStorm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC 29425, USAEmail gouveaalarissa@gmail.comPurpose: To assess optical quality dynamics using a double-pass (DP) system in patients with dry eye disease (DED).Methods: Seventy-six eyes with DED and 44 control subjects were enrolled in this study. Each patient underwent ocular surface evaluation including fluorescein corneal staining and Schirmer’s II test. Ocular Surface Disease Index (OSDI) questionnaire was used to assess subjective symptoms. Optical quality dynamics and tear film instability was analyzed using a DP system (HD AnalyzerTM, Visiometrics, Spain). Mean objective scatter index (OSI), maximum and minimum OSI, difference between maximum and minimum OSI (ΔOSI) were recorded with 40 consecutive scans over 20 s.Results: The DED group had pronounced impairment of optical quality compared to the control group. Mean OSI (4.29±4.07), minimum (3.22±3.51) and maximum (5.72±4.52) OSI, ΔOSI (2.50±1.96), OSDI score (36.94±16.55), and fluorescein corneal staining (0.79±0.96) were statistically significantly higher than controls (p<0.05). Schirmer’s II test was statistically significantly lower in the DED group compared to controls (10.08±7.85, 26.41±6.75, respectively; p<0.001). Three patterns of dynamic changes of OSI were proposed: ladder (continuous increase of OSI), seesaw (instability of OSI without improvement after blinking), and plateau (steady-high OSI). The ladder group showed the highest value of maximum OSI (6.93±4.13; p=0.03) and ΔOSI (3.76±2.08; p<0.001).Conclusion: DP imaging system provides an objective measurement of the visual quality in DED. Tear film instability may be assessed by dynamic changes of OSI over 20 s. In particular, the highest OSI values were observed in the ladder pattern group.Keywords: dry eye disease, quality of vision, tear film analysis, double-pass imaging system, objective scatter index, ocular surface disease index, fluorescein corneal staining, Schirmer’s testhttps://www.dovepress.com/objective-assessment-of-optical-quality-in-dry-eye-disease-using-a-dou-peer-reviewed-article-OPTHDry eye diseasequality of visiontear film analysisdouble-pass imaging systemobjective scatter indexocular surface disease indexfluorescein corneal stainingSchirmer’s test |
| spellingShingle | Gouvea L Waring GO IV Brundrett A Crouse M Rocha KM Objective assessment of optical quality in dry eye disease using a double-pass imaging system Clinical Ophthalmology Dry eye disease quality of vision tear film analysis double-pass imaging system objective scatter index ocular surface disease index fluorescein corneal staining Schirmer’s test |
| title | Objective assessment of optical quality in dry eye disease using a double-pass imaging system |
| title_full | Objective assessment of optical quality in dry eye disease using a double-pass imaging system |
| title_fullStr | Objective assessment of optical quality in dry eye disease using a double-pass imaging system |
| title_full_unstemmed | Objective assessment of optical quality in dry eye disease using a double-pass imaging system |
| title_short | Objective assessment of optical quality in dry eye disease using a double-pass imaging system |
| title_sort | objective assessment of optical quality in dry eye disease using a double pass imaging system |
| topic | Dry eye disease quality of vision tear film analysis double-pass imaging system objective scatter index ocular surface disease index fluorescein corneal staining Schirmer’s test |
| url | https://www.dovepress.com/objective-assessment-of-optical-quality-in-dry-eye-disease-using-a-dou-peer-reviewed-article-OPTH |
| work_keys_str_mv | AT gouveal objectiveassessmentofopticalqualityindryeyediseaseusingadoublepassimagingsystem AT waringgoiv objectiveassessmentofopticalqualityindryeyediseaseusingadoublepassimagingsystem AT brundretta objectiveassessmentofopticalqualityindryeyediseaseusingadoublepassimagingsystem AT crousem objectiveassessmentofopticalqualityindryeyediseaseusingadoublepassimagingsystem AT rochakm objectiveassessmentofopticalqualityindryeyediseaseusingadoublepassimagingsystem |