Immunological microenvironment in the testis
Abstract Background The testis is specific in that it produces haploid germ cells of which autoantigens newly appear long after the neonatal immune tolerance. Under normal condition, these autoantigens are protected by the blood‐testis barrier formed by Sertoli cells. Thus, the testis is an immunolo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12293 |
| _version_ | 1811326519733125120 |
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| author | Ning Qu Yuki Ogawa Miyuki Kuramasu Kenta Nagahori Kou Sakabe Masahiro Itoh |
| author_facet | Ning Qu Yuki Ogawa Miyuki Kuramasu Kenta Nagahori Kou Sakabe Masahiro Itoh |
| author_sort | Ning Qu |
| collection | DOAJ |
| description | Abstract Background The testis is specific in that it produces haploid germ cells of which autoantigens newly appear long after the neonatal immune tolerance. Under normal condition, these autoantigens are protected by the blood‐testis barrier formed by Sertoli cells. Thus, the testis is an immunologically privileged site where haploid cells are protected from autoimmune attack. Methods The immunological microenvironment in the testis was experimentally investigated using mice and rats. Main findings Not only the blood‐testis barrier but also various immuno‐suppressive factors are involved in the immune‐privileged testis. Indeed, germ cells transplanted into the xenogeneic seminiferous tubules could proliferate and differentiate with no aid of artificial immunosuppression. On the other hand, autoimmune orchitis could be experimentally produced by various methods of immunization with syngeneic or xenogeneic germ cell antigens. Conclusion Our results indicate that the testis is immunologically privileged but also immunologically fragile organ. Therefore, the dual nature is critical for immunoregulation of testicular function. |
| first_indexed | 2024-04-13T14:51:32Z |
| format | Article |
| id | doaj.art-6ae0cf568a434e1281f7e6826061c412 |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-04-13T14:51:32Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-6ae0cf568a434e1281f7e6826061c4122022-12-22T02:42:35ZengWileyReproductive Medicine and Biology1445-57811447-05782020-01-01191243110.1002/rmb2.12293Immunological microenvironment in the testisNing Qu0Yuki Ogawa1Miyuki Kuramasu2Kenta Nagahori3Kou Sakabe4Masahiro Itoh5Department of Anatomy Tokyo Medical University Tokyo JapanDepartment of Anatomy Tokyo Medical University Tokyo JapanDepartment of Anatomy Tokyo Medical University Tokyo JapanDepartment of Anatomy Tokyo Medical University Tokyo JapanDepartment of Anatomy, Division of Basic Medical Science Tokai University School of Medicine Kanagawa JapanDepartment of Anatomy Tokyo Medical University Tokyo JapanAbstract Background The testis is specific in that it produces haploid germ cells of which autoantigens newly appear long after the neonatal immune tolerance. Under normal condition, these autoantigens are protected by the blood‐testis barrier formed by Sertoli cells. Thus, the testis is an immunologically privileged site where haploid cells are protected from autoimmune attack. Methods The immunological microenvironment in the testis was experimentally investigated using mice and rats. Main findings Not only the blood‐testis barrier but also various immuno‐suppressive factors are involved in the immune‐privileged testis. Indeed, germ cells transplanted into the xenogeneic seminiferous tubules could proliferate and differentiate with no aid of artificial immunosuppression. On the other hand, autoimmune orchitis could be experimentally produced by various methods of immunization with syngeneic or xenogeneic germ cell antigens. Conclusion Our results indicate that the testis is immunologically privileged but also immunologically fragile organ. Therefore, the dual nature is critical for immunoregulation of testicular function.https://doi.org/10.1002/rmb2.12293andrologyimmunologyspermatogenesis |
| spellingShingle | Ning Qu Yuki Ogawa Miyuki Kuramasu Kenta Nagahori Kou Sakabe Masahiro Itoh Immunological microenvironment in the testis Reproductive Medicine and Biology andrology immunology spermatogenesis |
| title | Immunological microenvironment in the testis |
| title_full | Immunological microenvironment in the testis |
| title_fullStr | Immunological microenvironment in the testis |
| title_full_unstemmed | Immunological microenvironment in the testis |
| title_short | Immunological microenvironment in the testis |
| title_sort | immunological microenvironment in the testis |
| topic | andrology immunology spermatogenesis |
| url | https://doi.org/10.1002/rmb2.12293 |
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